Drug eluting ocular implant with anchor and methods thereof

• US 8,118,768 B2
• Filed: 10/06/2008
• Issued: 02/21/2012
• Est. Priority Date: 04/07/2001
• Status: Expired due to Term

• Current Assignee: Glaukos Corporation
• Original Assignee: DOSE Medical Corporation (Glaukos Corporation)
• Inventors: Tu, Hosheng, Artof, Jason, Haffner, David
• Primary Examiner(s): DEAK, LESLIE R
• Application Number:
  US12/246,448
• Publication Number:
  US 20090036819A1
• Time in Patent Office: 1,233 Days
• Field of Search: 604 7- 10, 604/264, 606/153
• US Class Current: 604/8
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 31/215 of carboxylic acids

Abstract

Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.

Claims

1. A method of treating an ocular disorder, comprising:

inserting an implant on one side of an eye, the implant having an anchor on a distal end portion and an outlet opening disposed proximal of the anchor, the anchor having a sharp end at a distal-most end of the distal end portion;

advancing the implant across the eye to the other side of the eye;

inserting the anchor into eye tissue on the other side of the eye; and

eluting a therapeutic agent using the implant.

2. The method of claim 1, wherein eluting a therapeutic agent involves eluting the therapeutic agent from a body of the implant.

3. The method of claim 1, wherein eluting a therapeutic agent involves eluting the therapeutic agent from the outlet opening.

4. The method of claim 1, wherein the method further comprises conducting fluid through the implant from one or more inlet openings to at least said outlet opening.

5. The method of claim 4, wherein conducting fluid through the implant involves conducting fluid from an anterior chamber of the eye.

6. The method of claim 4, wherein conducting fluid through the implant involves conducting fluid to a physiologic outflow pathway of the eye.

7. The method of claim 4, wherein conducting fluid through the implant involves conducting fluid to a choroid of the eye.

8. The method of claim 4, wherein conducting fluid through the implant involves conducting fluid towards a choroid of the eye.

9. The method of claim 1, wherein inserting the anchor involves embedding the anchor in scleral tissue such that the anchor only partially penetrates the sclera.

10. The method of claim 1, wherein advancing the implant involves placing at least a portion of the implant in contact with a choroid of the eye.

11. The method of claim 1, wherein advancing the implant involves advancing the implant across an anterior chamber of the eye.

12. The method of claim 1, wherein eluting a therapeutic agent involves releasing the therapeutic agent into a location adjacent to a choroid of the eye.

13. The method of claim 12, wherein releasing the therapeutic agent involves releasing the therapeutic agent from a body of the implant.

14. The method of claim 12, wherein releasing the therapeutic agent involves releasing the therapeutic agent from through the outlet opening.

15. The method of claim 1, wherein the method further comprises draining aqueous humor from an anterior chamber of the eye through the implant toward a choroid of the eye.

16. The method of claim 1, wherein the method further comprises controlling flow of fluid through the implant.

17. The method of claim 16, wherein controlling flow of fluid involves controlling flow through the implant using a valve.

18. The method of claim 1, wherein the method further comprises creating a corneal incision and introducing the implant into an anterior chamber of the eye through the incision.

19. The method of claim 1, wherein the implant has at least two outlet openings disposed proximal of the anchor.

20. The method of claim 1, wherein the anchor comprises a distally tapering structure.

21. The method of claim 1, wherein inserting the anchor involves disposing the anchor within ocular tissue such that at least a portion of the anchor is in contact with scleral tissue.