Porous membranes for use with implantable devices
First Claim
1. A biointerface membrane suitable for implantation in a soft tissue, the membrane comprising layers of:
- a first domain comprising an open cell configuration having a plurality of interconnected cavities and a solid portion, wherein the first domain has a depth of greater than one cavity in three dimensions substantially throughout an entirety of the first domain, and wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to redirect fibrous tissue contracture in vivo, thereby interfering with barrier cell layer formation within or around the first domain, and wherein a substantial number of the interconnected cavities are greater than or equal to about 90 microns in at least one dimension; and
a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes;
wherein the first and second domain layers are adhered together to form a unitary structure.
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Accused Products
Abstract
A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.
565 Citations
22 Claims
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1. A biointerface membrane suitable for implantation in a soft tissue, the membrane comprising layers of:
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a first domain comprising an open cell configuration having a plurality of interconnected cavities and a solid portion, wherein the first domain has a depth of greater than one cavity in three dimensions substantially throughout an entirety of the first domain, and wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to redirect fibrous tissue contracture in vivo, thereby interfering with barrier cell layer formation within or around the first domain, and wherein a substantial number of the interconnected cavities are greater than or equal to about 90 microns in at least one dimension; and a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes; wherein the first and second domain layers are adhered together to form a unitary structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A membrane suitable for implantation in a soft tissue, the membrane comprising layers of:
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a first domain, the first domain comprising an open cell configuration having a plurality of interconnected cavities and a solid portion; and a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes, wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to create a contractile force directed against the solid portion that counteracts a generally uniform downward fibrous tissue contracture caused by a foreign body response in vivo, thereby interfering with barrier cell layer formation proximal to the second domain, and wherein a substantial number of the interconnected cavities are greater than or equal to about 90 microns in at least one dimension; wherein the first and second domain layers are adhered together to form a unitary structure. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of monitoring an analyte level, the method comprising:
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providing an implantable device configured to monitor the analyte level, the implantable device comprising a biointerface membrane, wherein the biointerface membrane comprises; a first domain, wherein the first domain comprises a plurality of interconnected cavities and a solid portion, wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to create a contractile force directed against the solid portion that counteracts a generally uniform downward fibrous tissue contracture caused by a foreign body response in vivo, thereby interfering with barrier cell layer formation within or around the first domain; and a second domain adjacent to the first domain, the second domain allowing passage of the analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes; and monitoring the analyte level utilizing the implantable device. - View Dependent Claims (22)
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Specification