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Foamable compositions, kits and methods for hyperhidrosis

  • US 8,119,109 B2
  • Filed: 03/13/2007
  • Issued: 02/21/2012
  • Est. Priority Date: 10/25/2002
  • Status: Active Grant
First Claim
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1. A method of treating a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves excessive sweating as one of its symptoms, comprising:

  • a) dispensing a foamable composition comprising a propellant and less than 5% short chain alcohols, having up to 5 carbon atoms in their carbon chain skeleton and one hydroxyl group, wherein the composition is stored in an aerosol container and upon dispensing the foamable composition forms a thermally stable breakable foam, the breakable foam composition comprising;

    i. an active agent, suitable for the treatment of hyperhidrosis;

    ii. about 2% to about 50% by weight of at least one carrier selected from the group consisting of a hydrophobic organic carrier, a solvent, an emollient and any mixture thereof;

    iii. about 0.1% to about 5% by weight of a surface-active agent;

    iv. about 0.01% to about 5% by weight of a polymeric agent selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and

    v. water,b) administering the resulting breakable foam topically to a subject having the disorder, wherein the foam does not collapse immediately upon exposure to skin temperature, andc) collapsing the breakable foam by applying shear force to the administered breakable foam such that it is spread at, about and within the target site;

    wherein the active agent is administered in a therapeutically effective amount; and

    wherein the composition has some or partial resistance to centrifugation at 3000 rpm for 10 minutes.

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