Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
First Claim
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1. An aqueous contact lens cleaning and disinfecting solution composition comprising:
- 0.8 ppm to 1.6 ppm of poly(hexamethylene biguanide);
0.5 ppm to 2 ppm α
-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω
-tris(2-hydroxyethyl)ammonium chloride;
0.005 wt. % to 0.015 wt. % hyaluronic acid;
0.01 wt. % to 0.6 wt. % of a sulfobetaine of general formula I
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Abstract
Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 0.15 wt. % of hyaluronic acid; and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I
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- wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
32 Citations
12 Claims
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1. An aqueous contact lens cleaning and disinfecting solution composition comprising:
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0.8 ppm to 1.6 ppm of poly(hexamethylene biguanide); 0.5 ppm to 2 ppm α
-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω
-tris(2-hydroxyethyl)ammonium chloride;0.005 wt. % to 0.015 wt. % hyaluronic acid; 0.01 wt. % to 0.6 wt. % of a sulfobetaine of general formula I - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An aqueous contact lens care solution composition comprising:
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1 ppm to 1.3 ppm of poly(hexamethylene biguanide); 1 ppm α
-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω
-tris(2-hydroxyethyl)ammonium chloride;0.008 wt. % to 0.015 wt. % hyaluronic acid; and a borate buffer system component selected from the group consisting of boric acid and borate. - View Dependent Claims (11, 12)
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Specification