Nanoparticulate and controlled release compositions comprising cefditoren
First Claim
1. A stable nanoparticulate composition comprising:
- (A) particles comprising cefditoren or salts or prodrugs thereof, said particles having an effective average particle size of less than about 2000 nm in diameter;
(B) at least one surface stabilizers, adsorbed on the surface of said cefditoren particles, and (C) docusate sodium in sufficient amounts to produce a pharmacokinetic profile wherein the administration of the composition to a subject in a fasted state is bioequivalent to the administration of the composition to a subject in the fed state.
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Abstract
The present invention provides a composition comprising a cefditoren, or a salt, derivative, prodrug, or other form thereof, for example, cefditoren pivoxil, useful in the treatment and prevention of infections and related conditions. The invention provides a composition which comprises nanoparticulate particles comprising the cefditoren, or a salt, derivative, prodrug, or other form thereof and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. The invention provides also a composition that delivers a cefditoren, or a salt, derivative, prodrug, or other form thereof, or nanoparticles comprising the same, in a pulsatile or continuous manner.
211 Citations
22 Claims
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1. A stable nanoparticulate composition comprising:
- (A) particles comprising cefditoren or salts or prodrugs thereof, said particles having an effective average particle size of less than about 2000 nm in diameter;
(B) at least one surface stabilizers, adsorbed on the surface of said cefditoren particles, and (C) docusate sodium in sufficient amounts to produce a pharmacokinetic profile wherein the administration of the composition to a subject in a fasted state is bioequivalent to the administration of the composition to a subject in the fed state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- (A) particles comprising cefditoren or salts or prodrugs thereof, said particles having an effective average particle size of less than about 2000 nm in diameter;
Specification