Cell culture devices having ultrathin porous membrane and uses thereof
First Claim
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1. A cell culture device comprising:
- first and second chambers separated by at least one nanoscale semiconductor membrane positioned between the first and second chambers, the at least one nanoscale membrane having an average thickness of less than about 100 nm, and having a plurality of pores extending between opposite sides thereof.
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Abstract
Disclosed is a device for co-culturing two or more populations of cells using ultrathin, porous membranes positioned between cell culture chambers. Multiple chamber devices and uses thereof are described, including the formation of in vitro tissue models for studying drug delivery, cell-cell interactions, and the activity of low abundance molecular species.
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Citations
51 Claims
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1. A cell culture device comprising:
first and second chambers separated by at least one nanoscale semiconductor membrane positioned between the first and second chambers, the at least one nanoscale membrane having an average thickness of less than about 100 nm, and having a plurality of pores extending between opposite sides thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
Specification