Photoacoustic measurement of analyte concentration in the eye
First Claim
1. A method of measuring the blood concentration of a substance in vivo, the method comprisingilluminating the aqueous or vitreous humor or retinal fluid with a light source at a frequency that is absorbed by the substance to be measured,sensing only photoacoustically generated pulses or modulating acoustic signals originated within the aqueous or vitreous humor or retinal fluid as a consequence of illumination by the light source, without light being reflected or otherwise directed to a detector,estimating blood concentration of the substance from an amplitude of received pulses or modulating acoustic signals, anddisplaying the estimated blood concentration.
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Abstract
In one aspect, the invention features a method and device for measuring blood concentration of a substance such as glucose in the aqueous humor by illuminating the aqueous humor with a light source at a frequency that is absorbed by the substance to the measured, and then sensing photoacoustically generated sound waves originated within the aqueous humor as a consequence of illumination by the light source. The blood concentration can be estimated from the amplitude of the sound waves received. The method may be combined with other optical techniques for glucose measurement and/or with optical or ultrasonic techniques for topographic mapping of eye structures.
31 Citations
14 Claims
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1. A method of measuring the blood concentration of a substance in vivo, the method comprising
illuminating the aqueous or vitreous humor or retinal fluid with a light source at a frequency that is absorbed by the substance to be measured, sensing only photoacoustically generated pulses or modulating acoustic signals originated within the aqueous or vitreous humor or retinal fluid as a consequence of illumination by the light source, without light being reflected or otherwise directed to a detector, estimating blood concentration of the substance from an amplitude of received pulses or modulating acoustic signals, and displaying the estimated blood concentration.
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5. An in vivo photoacoustic method of measuring the blood concentration of a substance, the method comprising
illuminating a retinal surface with a light source at a frequency that is absorbed by the substance to be measured, sensing only photoacoustically generated pulses or modulating acoustic signals originated within the eye as a consequence of illumination by the light source, without light being reflected or otherwise directed to a detector, estimating blood concentration of the substance from an amplitude of received pulses or modulating acoustic signals only, and displaying the estimated blood concentration of the substance, the method photoacoustically measuring in vivo the blood concentration of the substance.
Specification