Cardiac motion characterization by strain measurement
First Claim
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1. A method for evaluating movement of a cardiac tissue location in a subject, the method comprising:
- (a) determining timing of a signal obtained from a resistive strain gauge of an implantable device stably associated with the cardiac tissue location, wherein the implantable device comprises;
a lead of a length with a proximal end and a distal end, the lead comprising;
a guide wire core formed within the lead along the length of the lead, wherein the resistive strain gauge is physically attached to the guide wire core; and
at least one insulated conductor spirally wrapping the guide wire core from the proximal end to the distal end, wherein the resistive strain gauge is electrically coupled to an insulated conductor of the at least one insulated conductor; and
(b) evaluating movement of the cardiac tissue location via a signal processing element communicatively coupled to the implantable device based on the timing of the signal obtained from the resistive strain gauge.
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Abstract
Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
41 Citations
31 Claims
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1. A method for evaluating movement of a cardiac tissue location in a subject, the method comprising:
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(a) determining timing of a signal obtained from a resistive strain gauge of an implantable device stably associated with the cardiac tissue location, wherein the implantable device comprises; a lead of a length with a proximal end and a distal end, the lead comprising; a guide wire core formed within the lead along the length of the lead, wherein the resistive strain gauge is physically attached to the guide wire core; and at least one insulated conductor spirally wrapping the guide wire core from the proximal end to the distal end, wherein the resistive strain gauge is electrically coupled to an insulated conductor of the at least one insulated conductor; and (b) evaluating movement of the cardiac tissue location via a signal processing element communicatively coupled to the implantable device based on the timing of the signal obtained from the resistive strain gauge. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A system for evaluating movement of a cardiac tissue location, the system comprising:
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(a) an implantable device comprising; a lead of a length with a proximal end and a distal end, the lead comprising; a guide wire core formed within the lead along the length of the lead; a resistive strain gauge physically attached to the guide wire core; and at least one insulated conductor spirally wrapping the guide wire core from the proximal end to the distal end, wherein the resistive strain gauge is electrically coupled to an insulated conductor of the at least one insulated conductor, and the resistive strain gauge stably associated with the cardiac tissue location; and (b) a signal processing element communicatively coupled to the implantable device and configured to employ timing of a signal obtained from the resistive strain gauge that is induced by movement of the cardiac tissue location to evaluate movement of the cardiac tissue location.
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23. An implantable device comprising:
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a lead of a length with a proximal end and a distal end, the lead comprising; a guide wire core formed within the lead along the length of the lead; a resistive strain gauge physically attached to the guide wire core; and at least one insulated conductor spirally wrapping the guide wire core from the proximal end to the distal end, wherein the resistive strain gauge is electrically coupled to an insulated conductor of the at least one insulated conductor. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31)
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Specification