Control arrangement for microfluidic devices and related methods and systems
First Claim
Patent Images
1. A control arrangement for a fluidic circuit comprising one or more fluid channels, comprising:
- a deformable membrane defining at least one surface of each of the one or more fluid channels, wherein the deformable membrane is formed with the one or more fluid channels in a monolithic microfluidic circuit;
an actuating arrangement comprising one or more actuating pins for deforming the deformable membrane, thus controlling flow in the one or more fluid channels by opening and/or closing the one or more fluid channels,wherein the deformable membrane is made of the same material defining other surfaces of the one or more fluid channels.
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Abstract
Communication between microchannels of a microfluidic circuit is controlled through a combination between a membrane and a pin-actuated valve arrangement. The deformable membrane contributes to the formation of the surface of the microchannels. Alternatively, or in addition, the valve arrangement is operated through combination of the membrane with a control fluid. Systems, devices and methods based on such communication are shown. Also shown are methods to manufacture a system having a fluidic circuit and a control arrangement.
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Citations
19 Claims
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1. A control arrangement for a fluidic circuit comprising one or more fluid channels, comprising:
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a deformable membrane defining at least one surface of each of the one or more fluid channels, wherein the deformable membrane is formed with the one or more fluid channels in a monolithic microfluidic circuit; an actuating arrangement comprising one or more actuating pins for deforming the deformable membrane, thus controlling flow in the one or more fluid channels by opening and/or closing the one or more fluid channels, wherein the deformable membrane is made of the same material defining other surfaces of the one or more fluid channels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system with a fluidic circuit and a control arrangement for the fluidic circuit, the fluidic circuit including one or more fluid channels, the control arrangement comprising:
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a deformable membrane defining at least one surface of each of the one or more fluid channels, wherein the deformable membrane is formed with the one or more fluid channels in a monolithic microfluidic circuit; and an actuating arrangement comprising one or more actuating pins for deforming the deformable membrane, thus controlling flow in the one or more fluid channels by opening and/or closing the one or more fluid channels, the system comprising; a reinforcing layer keeping the fluidic circuit and the deformable membrane together, wherein the reinforcing layer comprises holes to allow passage of the one or more actuating pins. - View Dependent Claims (12, 13)
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14. A control arrangement for a fluidic circuit comprising one or more fluid channels, comprising:
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a deformable membrane defining at least one surface of each of the one or more fluid channels, wherein the deformable membrane is formed with the one or more fluid channels in a monolithic microfluidic circuit; an actuating arrangement comprising one or more actuating pins for deforming the deformable membrane, thus controlling flow in the one or more fluid channels by opening and/or closing the one or more fluid channels; a first storage compartment and a second storage compartment, the first storage compartment fluidly in communication with the second storage compartment; and one or more fingers and clamps, configured to deform the deformable membrane to seal the one or more fluid channels, wherein the deformed deformable membrane maintains fluidic separation between the first storage compartment and the second storage compartment. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification