Modified implantable device surface and a method of making the same

• US 8,123,799 B1
• Filed: 11/30/2001
• Issued: 02/28/2012
• Est. Priority Date: 11/30/2001
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Malik, Shamim M., Claude, Charles D., Hossainy, Syed F. A.
• Primary Examiner(s): TYSON, MELANIE RUANO
• Application Number:
  US09/997,449
• Time in Patent Office: 3,742 Days
• Field of Search: 623 142- 146, 623/1.39, 623/1.4, 623/1.15, 623/1.13, 427 224- 225, 427/2.3, 427/577, 427/525, 427/530, 209/192.16
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: B05D 1/62 Plasma-deposition of organic layers plasma deposition in general C23C14/00, C23C16/00
• CPC Class Codes: B05D 2502/00 Acrylic polymers
• CPC Class Codes: C08L 33/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C23C 16/26 Deposition of carbon only
• CPC Class Codes: H01J 37/32082 Radio frequency generated discharge H01J37/32357, H01J37/32366, H01J37/32394 and H01J37/32403 take precedence

Abstract

A medical device, such as a stent, is disclosed having a modified surface. A method of making the modification is also disclosed. The modification includes depositing a substance within the surface of the device and forming a film layer on the surface of the device. The substance can include carbon and the film layer can be a polymeric layer, such as a plasma polymerized organic film layer.

Claims

1. A stent comprising:

a metallic stent body having a stent body surface;

a molecular carbon deposit present at a depth of not more than about 2000 Å

beneath the stent body surface; and

a plasma-polymerized polymer film layer deposited over the stent body surface and in intimate contact with the stent body surface, wherein the plasma-polymerized film layer is chemically bonded to the carbon deposit.

2. The stent of claim 1, wherein the plasma-polymerized polymer film layer comprises an acrylate.

3. The stent of claim 1, wherein the plasma-polymerized polymer film layer is formed by exposing the stent to an acrylic acid plasma.

4. The stent of claim 1, wherein the plasma polymerized film layer comprises functional groups selected from the group consisting of carboxylate, amine and sulfate.

5. The stent of claim 1, wherein the surface of the stent is the tissue-contacting surface of the stent body.

6. The stent of claim 1, wherein the metallic stent body comprises stainless steel.

7. The stent of claim 1, further comprising a polymeric layer comprising a therapeutic substance formed on the plasma-polymerized polymer film layer.

8. The stent of claim 1, wherein the metallic stent body comprises a radially expandable tubular body.

9. The stent of claim 1, wherein the metallic stent body comprises an alloy.