Propellant-based nanoparticulate dry powder aerosols and method of making
First Claim
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1. A method for making a propellant-based dry powder composition, comprising:
- (a) obtaining dry powder of a nanoparticulate drug composition; and
then(b) dispersing the dry powder in at least one propellant,wherein the nanoparticulate drug composition;
(i) comprises a poorly soluble drug, (ii) has an effective average particle size of less than 1000 nm or equal to about 1000 nm, and (iii) has a surface modifier adsorbed on the surface of the drug particles, andwherein step (a) comprises;
(i) forming an aqueous nanoparticulate dispersion of the drug and surface modifier; and
(ii) spray-drying or freeze-drying the nanoparticulate dispersion to form a dry powder of spherically shaped aggregates of the nanoparticulate drug and surface modifier, wherein the aggregates have a diameter of less than 100 microns or equal to about 100 microns.
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Abstract
There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
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Citations
9 Claims
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1. A method for making a propellant-based dry powder composition, comprising:
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(a) obtaining dry powder of a nanoparticulate drug composition; and
then(b) dispersing the dry powder in at least one propellant, wherein the nanoparticulate drug composition;
(i) comprises a poorly soluble drug, (ii) has an effective average particle size of less than 1000 nm or equal to about 1000 nm, and (iii) has a surface modifier adsorbed on the surface of the drug particles, andwherein step (a) comprises; (i) forming an aqueous nanoparticulate dispersion of the drug and surface modifier; and (ii) spray-drying or freeze-drying the nanoparticulate dispersion to form a dry powder of spherically shaped aggregates of the nanoparticulate drug and surface modifier, wherein the aggregates have a diameter of less than 100 microns or equal to about 100 microns. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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