Coatings for drug delivery devices

• US 8,124,119 B2
• Filed: 07/29/2009
• Issued: 02/28/2012
• Est. Priority Date: 11/12/2001
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Pacetti, Stephen Dirk
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): YOUNG, MICAH PAUL
• Application Number:
  US12/511,919
• Publication Number:
  US 20090291882A1
• Time in Patent Office: 944 Days
• Field of Search: 424424-426
• US Class Current: 424/424
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/30 Inorganic materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: C08L 29/02 Homopolymers or copolymers of unsaturated alcohols C08L29/14 takes precedence
• CPC Class Codes: C09D 129/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C09D 129/06 Copolymers of allyl alcohol

Abstract

A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

Claims

1. A coating disposed on a medical device, the coating comprising a polymer that comprises poly(ethylene-co-α

-methvinyl alcohol).

2. The coating of claim 1, wherein the coating is a primer layer.

3. The coating of claim 1, wherein the coating is a rate release limiting membrane.

4. The coating of claim 1, wherein the polymer absorbs not more than 5% of water by mass.

5. The coating of claim 1, wherein the polymer is soluble in an organic solvent.

6. The coating of claim 1, wherein the polymer has a tensile strength of not less than about 24 MPa (3,500 pounds per square inch).

7. The coating of claim 1, wherein the polymer has an ultimate elongation exceeding 30 percent.

8. The coating of claim 1, further comprises an active agent.

9. The coating of claim 8, wherein the active agent is selected from the group consisting of antineoplastic, anti-inflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antiallergic and antioxidant substances.

10. The coating of claim 8, wherein the active agent is an antiproliferative substance.

11. The coating of claim 8, wherein the active agent is rapamycin.

12. The coating of claim 8, wherein the active agent is actinomycin D.

13. The coating of claim 1, wherein the medical device is a stent.

14. The coating of claim 8, wherein the medical device is a stent.

15. The coating of claim 9, wherein the medical device is a stent.

16. The coating of claim 10, wherein the medical device is a stent.

17. The coating of claim 11, wherein the medical device is a stent.

18. The coating of claim 12, wherein the medical device is a stent.