Murine zcytor17 ligand polynucleotides
First Claim
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1. An isolated polynucleotide, wherein the polynucleotide encodes a polypeptide comprising the sequence of amino acid residues having at least 96% identity to:
- (a) amino acid residues 31 to 163 as shown in SEQ ID NO;
11;
or (b) amino acid residues 1 to 163 as shown in SEQ ID NO;
11.
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Abstract
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
22 Citations
16 Claims
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1. An isolated polynucleotide, wherein the polynucleotide encodes a polypeptide comprising the sequence of amino acid residues having at least 96% identity to:
- (a) amino acid residues 31 to 163 as shown in SEQ ID NO;
11;
or (b) amino acid residues 1 to 163 as shown in SEQ ID NO;
11. - View Dependent Claims (2, 6, 7, 8, 9, 10, 12, 13, 14)
- (a) amino acid residues 31 to 163 as shown in SEQ ID NO;
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3. An isolated polynucleotide, wherein the polynucleotide encodes a polypeptide comprising the sequence of amino acid residues selected from the group consisting of:
- (a) amino acid residues 31 to 163 as shown in SEQ ID NO;
11; and
(b) amino acid residues 1 to 163 as shown in SEQ ID NO;
11. - View Dependent Claims (4, 5)
- (a) amino acid residues 31 to 163 as shown in SEQ ID NO;
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11. An isolated polynucleotide comprising the sequence of nucleotides from nucleotide 91 to nucleotide 489 of SEQ ID NO:
- 10.
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15. An isolated polynucleotide, wherein the polynucleotide encodes a polypeptide comprising the amino acid sequence selected from the group consisting of:
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(a) a polypeptide comprising the amino acid sequence of SEQ ID NO;
11 from amino acid number 38-157; and(b) a polypeptide comprising the amino acid sequence of SEQ ID NO;
11 from amino acid number 24-163.
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16. An isolated polynucleotide encoding an antigenic polypeptide comprising a sequence of at least 30 contiguous amino acid residues of SEQ ID NO:
- 11, wherein the antigenic polypeptide comprises the amino acid sequence selected from;
(a) amino acid residues 34 to 39 of SEQ ID NO;
11;(b) amino acid residues 46 to 51 of SEQ ID NO;
11;(c) amino acid residues 131 to 136 of SEQ ID NO;
11;(d) amino acid residues 158 to 163 of SEQ ID NO;
11; and(e) amino acid residues 157 to 162 of SEQ ID NO;
11.
- 11, wherein the antigenic polypeptide comprises the amino acid sequence selected from;
Specification