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Encoded beads having oligonucleotides attached in arrays on a patterned surface

  • US 8,124,402 B2
  • Filed: 05/17/2006
  • Issued: 02/28/2012
  • Est. Priority Date: 04/25/1996
  • Status: Expired due to Fees
First Claim
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1. An ordered planar array comprising several different particle types with different oligonucleotides attached to different particle types, said particles up to 10 microns in diameter, wherein the relative positions of particular particle types with respect to other particular particle types in the array are random and are not determined before the planar array is formed, and said particles are encoded with a characteristic that permits identification of the oligonucleotides attached thereto and permits distinguishing and identifying the different particle types without removing the particles from the array, and wherein said particles are immobilized on a substrate in a spatially non-random, crystalline configuration such that the particles have portions of their surfaces facing corresponding portions of surfaces of other particles without physical barriers between said corresponding portions of surfaces.

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