Optimized Fc variants and methods for their generation
First Claim
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1. An antibody or immunoadhesin, wherein said antibody or immunoadhesin comprises an Fc variant of a human parent Fc polypeptide, said Fc variant comprising an amino acid substitution at position 299 in the Fc region and wherein numbering is according to the EU index.
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Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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4 Claims
- 1. An antibody or immunoadhesin, wherein said antibody or immunoadhesin comprises an Fc variant of a human parent Fc polypeptide, said Fc variant comprising an amino acid substitution at position 299 in the Fc region and wherein numbering is according to the EU index.
- 2. A protein comprising an Fc variant of a human parent Fc polypeptide, said Fc variant comprising an amino acid substitution at position 299 in the Fc region and wherein numbering is according to the EU index.
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