Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body
First Claim
1. A monitoring system for use in non-invasively monitoring at least one parameter of a region of interest in a human body, the system comprising:
- a measurement unit comprising;
an optical unit having an illumination assembly configured to define at least one output port for illuminating light, and a light detection assembly configured to define at least one light input port for collecting light scattered from the illuminated body portion and to generate measured data indicative of the collected light; and
an acoustic unit configured to generate acoustic waves of a predetermined ultrasound frequency range;
the measurement unit being configured and operable to provide an operating condition such that the acoustic waves of the predetermined frequency range overlap with an illuminating region within the region of interest and substantially do not overlap with a region outside the region of interest, and that the detection assembly collects light scattered from the region of interest and light scattered from the region outside the region of interest, the measured data being thereby indicative of scattered light having both ultrasound tagged and untagged light portions; and
a control unit, which is connectable to the optical unit and to the acoustic unit to operate these units,the control unit being responsive to the measured data and preprogrammed to;
process and analyze the measured data to extract therefrom a data portion associated with the light response of the region of interest and determine said at least one parameter of the region of interest, by;
interpreting the tagged light portions as having been at least partially scattered by the region of interest,interpreting the untagged light portions as having been scattered by the region outside of the region of interest, andextracting, from the tagged light portion of the measured data, the data portion associated with the light response of the region of interest, based on the untagged light portions of the measured data.
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Accused Products
Abstract
A method and system for noninvasive monitoring of at least one parameter of a region of interest in a human body. The system comprises a measurement unit and a control unit. The measurement unit comprises an optical unit having an illumination assembly (101A) and a light detection assembly (101B) to generate measured data indicative of collected light; and an acoustic unit (110) configured to generate acoustic waves of a predetermined ultrasound frequency range. The measurement unit provides an operating condition such that the acoustic waves overlap with an illuminating region within the region of interest and substantially do not overlap outside the region of interest. The measured data is indicative of scattered light having both ultrasound tagged and untagged light portions, enabling to distinguish between light responses of the region of interest and the region outside the region of interest.
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Citations
73 Claims
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1. A monitoring system for use in non-invasively monitoring at least one parameter of a region of interest in a human body, the system comprising:
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a measurement unit comprising; an optical unit having an illumination assembly configured to define at least one output port for illuminating light, and a light detection assembly configured to define at least one light input port for collecting light scattered from the illuminated body portion and to generate measured data indicative of the collected light; and an acoustic unit configured to generate acoustic waves of a predetermined ultrasound frequency range; the measurement unit being configured and operable to provide an operating condition such that the acoustic waves of the predetermined frequency range overlap with an illuminating region within the region of interest and substantially do not overlap with a region outside the region of interest, and that the detection assembly collects light scattered from the region of interest and light scattered from the region outside the region of interest, the measured data being thereby indicative of scattered light having both ultrasound tagged and untagged light portions; and a control unit, which is connectable to the optical unit and to the acoustic unit to operate these units, the control unit being responsive to the measured data and preprogrammed to; process and analyze the measured data to extract therefrom a data portion associated with the light response of the region of interest and determine said at least one parameter of the region of interest, by; interpreting the tagged light portions as having been at least partially scattered by the region of interest, interpreting the untagged light portions as having been scattered by the region outside of the region of interest, and extracting, from the tagged light portion of the measured data, the data portion associated with the light response of the region of interest, based on the untagged light portions of the measured data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method for use in noninvasive monitoring at least one parameter of a region of interest in a human body, the method comprising:
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operating an optical unit and an acoustic unit so as to provide that ultrasound waves of a predetermined frequency range and illuminating light overlap within the region of interest and substantially do not overlap with a region outside the region of interest, thereby producing measured data indicative of collected light including scattered light having ultrasound tagged and untagged light portions, interpreting the tagged light portions as having been at least partially scattered by the region of interest, interpreting the untagged light portions as having been scattered by the region outside of the region of interest, and extracting, from the tagged light portion of the measured data, the data portion associated with the light response of the region of interest, based on the untagged light portions of the measured data. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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69. A method for use in noninvasive monitoring oxygen saturation level, the method comprising:
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applying ultrasound tagging of light in pulse oxymetric measurements, obtaining measured data indicative of variations of collected light as a function of both time and wavelength of illuminating light, the collected light including scattered light having ultrasound tagged and untagged light portions, interpreting the tagged light portions as having been at least partially scattered by a region of interest, interpreting the untagged light portions as having been scattered by a region outside of the region of interest, and extracting, from the tagged light portion of the measured data, the data portion associated with the light response of the region of interest, based on the untagged light portion of the measured data, and analyzing the data portion associated with the light response of the region of interest to calculate the oxygen saturation level of the region of interest.
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70. A method for use in noninvasive monitoring at least one parameter of a fetus-related region of interest, the method comprising:
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providing an optical unit having an illumination assembly configured to define at least one output port for the illuminating light; and a light detection assembly configured to define at least one light input port for collecting light, and to generate measured data indicative of the collected light; and providing an acoustic unit configured to generate acoustic waves of a predetermined ultrasound frequency range; providing an optimal positioning of the optical and acoustic units with respect to each other and with respect to the fetus-related region of interest, said optimal positioning satisfying an operating condition resulting in that the ultrasound waves of the predetermined frequency range overlap with the illuminating light within the fetus-related region of interest, while substantially not overlapping in a maternal tissues region outside the fetus-related region of interest, and in that the detection assembly collects light scattered from the fetus-related region of interest and from the maternal tissues region; operating the optical and acoustic units, when in the optimal positioning, and generating measured data indicative of collected light including scattered light having ultrasound tagged and untagged light portions, interpreting the tagged light portions as having been at least partially scattered by the fetus-related region of interest, interpreting the untagged light portions as having been scattered by the maternal tissues region outside of the fetus-related region of interest, and extracting, from the tagged light portion of the measured data, the data portion associated with the light response of the fetus-related region of interest, based on the untagged light portions of the measured data. - View Dependent Claims (71, 72, 73)
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Specification