Method and apparatus for adjustment of sequential biventricular pacing parameters

• US 8,126,547 B2
• Filed: 12/14/2007
• Issued: 02/28/2012
• Est. Priority Date: 01/28/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kramer, Andrew P., Ding, Jiang
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US12/002,272
• Publication Number:
  US 20080097536A1
• Time in Patent Office: 1,537 Days
• Field of Search: 607/9, 607/15, 607/18, 607/23, 607/25, 607/30, 607/32, 607/59, 607/60
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.

Claims

1. A system for setting one of more pacing parameters used by an implantable cardiac rhythm management device in delivering cardiac resynchronization therapy, comprising:

an implantable cardiac rhythm management device that includes;

sensing channels for generating electrogram signals corresponding to electrical activity in an atrium, the right ventricle, and the left ventricle;

right and left ventricular pacing channels for delivering pacing pulses to the right and left ventricles, respectively;

a controller for interpreting electrogram signals and controlling the output of pacing pulses in a programmed pacing mode; and

a telemetry interface;

an external programmer in communication with the implantable device via the telemetry interface;

wherein the system is programmed to measure at least one intrinsic atrio-ventricular delay (AVD) interval from electrogram signals during an intrinsic beat and compute an optimum AVD interval for delivering ventricular pacing in an atrial tracking or AV sequential pacing mode in accordance with a formula which expresses the optimum AVD interval as a function of the measured intrinsic AVD interval;

wherein the system is programmed to measure the delay between right ventricular and left ventricular activation during an intrinsic beat, referred to as the Δ

_RL interval, and compute an optimum biventricular offset (BVO) interval in accordance with a formula which expresses the optimum BVO interval as a function of the measured Δ

_RL interval;

and,

wherein the system is programmed to select between a left ventricle-only pacing mode, a right ventricle-only pacing mode, and a biventricular pacing mode based upon the computed optimum BVO and AVD intervals.

2. The system of claim 1, wherein the system is programmed to select left ventricle-only pacing mode if the optimum BVO is smaller than a specified threshold T3 or if the difference between the optimum AVD and the optimum BVO is greater than the right intrinsic atrio-ventricular delay (AV_R) less a specified offset S1.

3. The system of claim 1, wherein the system is programmed to select right ventricle-only pacing if the optimum BVO is larger than a specified threshold T4 or if the sum of the optimum AVD and BVO intervals is greater than a measured left intrinsic atrio-ventricular delay (AV_L).

4. The system of claim 1 wherein:

the implantable device include a first electrode for pacing the left ventricular lateral free wall and a second electrode for pacing an anterior location of the left ventricle;

the system is programmed to measure Q*V_L as the interval from the start of left ventricular depolarization to a left ventricular sense; and

,

the system is programmed to select the second electrode for delivering left ventricular pacing if the Q*V_L parameter is less than a specified limit value and select the first electrode for delivering left ventricular pacing otherwise.

5. The system of claim 1 wherein:

the implantable device is equipped with electrodes for pacing two left ventricular pacing sites, L1 and L2;

the system is programmed to measure intrinsic conduction parameters AV_L1 and AV_LV2 as the intervals between an atrial sense and a left ventricular sense detected from electrograms generated at sites L1 and L2, respectively; and

,

the system is programmed to select the left ventricular pacing site that is excited later during an intrinsic beat as reflected by a longer AV delay interval.

6. The system of claim 1 wherein the optimum biventricular offset interval BVO is computed as:

BVO=k₁Δ

_RL+k₂

where k₁ and k₂ are specified coefficients.

7. The system of claim 1 wherein the optimum AVD is computed as:

AVD=k₁AV_R+k₂AV_L+k₃

wherein a right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, a left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a left ventricular sense designated as AV_L and wherein k₁, k₂, and k₃, are specified coefficients.

8. An implantable cardiac rhythm management device for delivering cardiac resynchronization therapy, comprising:

sensing channels for generating electrogram signals corresponding to electrical activity in an atrium, the right ventricle, and the left ventricle;

right and left ventricular pacing channels for delivering pacing pulses to the right and left ventricles, respectively;

a controller for interpreting electrogram signals and controlling the output of pacing pulses in a programmed pacing mode; and

a telemetry interface;

wherein the controller is programmed to measure at least one intrinsic atrio-ventricular delay (AVD) interval from electrogram signals during an intrinsic beat and compute an optimum AVD interval for delivering ventricular pacing in an atrial tracking or AV sequential pacing mode in accordance with a formula which expresses the optimum AVD interval as a function of the measured intrinsic AVD interval;

wherein the controller is programmed to measure the delay between right ventricular and left ventricular activation during an intrinsic beat, referred to as the Δ

_RL interval, and compute an optimum biventricular offset (BVO) interval in accordance with a formula which expresses the optimum BVO interval as a function of the measured Δ

_RL interval;

and,

wherein the controller is programmed to select between a left ventricle-only pacing mode, a right ventricle-only pacing mode, and a biventricular pacing mode based upon the computed optimum BVO and AVD intervals.

9. The device of claim 8, wherein the controller is programmed to select left ventricle-only pacing mode if the optimum BVO is smaller than a specified threshold T3 or if the difference between the optimum AVD and the optimum BVO is greater than the right intrinsic atrio-ventricular delay (AV_R) less a specified offset S1.

10. The device of claim 8, wherein the controller is programmed to select right ventricle-only pacing if the optimum BVO is larger than a specified threshold T4 or if the sum of the optimum AVD and BVO intervals is greater than a measured left intrinsic atrio-ventricular delay (AV_L).

11. The device of claim 8 further comprising:

a first electrode for pacing the left ventricular lateral free wall and a second electrode for pacing an anterior location of the left ventricle;

wherein the controller is programmed to measure Q*V_L as the interval from the start of left ventricular depolarization to a left ventricular sense; and

,

wherein the controller is programmed to select the second electrode for delivering left ventricular pacing if the Q*V_L parameter is less than a specified limit value and select the first electrode for delivering left ventricular pacing otherwise.

12. The device of claim 8, further comprising:

electrodes for pacing two left ventricular pacing sites, L1 and L2;

wherein the controller is programmed to measure intrinsic conduction parameters AV_L1 and AV_LV2 as the intervals between an atrial sense and a left ventricular sense detected from electrograms generated at sites L1 and L2, respectively; and

,

wherein the controller is programmed to select the left ventricular pacing site that is excited later during an intrinsic beat as reflected by a longer AV delay interval.

13. The device of claim 8 wherein the optimum biventricular offset interval BVO is computed as:

BVO=k₁Δ

_RL+k₂

where k₁ and k₂ are specified coefficients.

14. The device of claim 8 wherein the optimum AVD is computed as:

AVD=k₁AV_R+k₂AV_L+k₃

wherein a right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, a left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a left ventricular sense designated as AV_L and wherein k₁, k₂, and k₃, are specified coefficients.

15. A method for configuring an implantable cardiac rhythm management device for delivering cardiac resynchronization therapy, comprising:

generating electrogram signals corresponding to electrical activity in an atrium, the right ventricle, and the left ventricle;

measuring at least one intrinsic atrio-ventricular delay (AVD) interval from electrogram signals during an intrinsic beat and compute an optimum AVD interval for delivering ventricular pacing in an atrial tracking or AV sequential pacing mode in accordance with a formula which expresses the optimum AVD interval as a function of the measured intrinsic AVD interval;

measuring the delay between right ventricular and left ventricular activation during an intrinsic beat, referred to as the Δ

_RL interval, and compute an optimum biventricular offset (BVO) interval in accordance with a formula which expresses the optimum BVO interval as a function of the measured Δ

_RL interval;

and,

selecting between a left ventricle-only pacing mode, a right ventricle-only pacing mode, and a biventricular pacing mode based upon the computed optimum BVO and AVD intervals.

16. The method of claim 15 further comprising selecting a left ventricle-only pacing mode if the optimum BVO is smaller than a specified threshold T3 or if the difference between the optimum AVD and the optimum BVO is greater than the right intrinsic atrioventricular delay (AV_R) less a specified offset S1.

17. The method of claim 15 further comprising selecting a right ventricle-only pacing if the optimum BVO is larger than a specified threshold T4 or if the sum of the optimum AVD and BVO intervals is greater than a measured left intrinsic atrio-ventricular delay (AV_L).

18. The method of claim 15 further comprising:

measuring Q*V_L as the interval from the start of left ventricular depolarization to a left ventricular sense; and

,

selecting an electrode for delivering left ventricular pacing to an anterior location if the Q*V_L parameter is less than a specified limit value and selecting an electrode for delivering left ventricular pacing to a lateral free wall location otherwise.

19. The method of claim 15 further comprising:

measuring intrinsic conduction parameters AV_L1 and AV_LV2 as the intervals between an atrial sense and a left ventricular sense detected from electrograms generated at alternative left ventricular pacing sites L1 and L2, respectively; and

,

selecting the left ventricular pacing site that is excited later during an intrinsic beat as reflected by a longer AV delay interval.

20. The method of claim 15 wherein the optimum biventricular offset interval BVO is computed as:

BVO=k₁Δ

_RL+k₂

where k₁ and k₂ are specified coefficients.