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Implantable medical device with chemical sensor and related methods

  • US 8,126,554 B2
  • Filed: 05/17/2006
  • Issued: 02/28/2012
  • Est. Priority Date: 05/17/2006
  • Status: Active Grant
First Claim
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1. A method for monitoring diuretic therapy comprising:

  • optically sensing a physiological concentration of an analyte in a bodily fluid of a patient with a chronically implanted chemical sensor, the chemical sensor comprising;

    a sensing element comprising a potassium ion selective complexing moiety, the potassium ion selective complexing moiety selected from the group comprising cryptands, crown ethers, bis-crown ethers, calixarenes, noncyclic amides, and hemispherands;

    an excitation assembly configured to illuminate the sensing element;

    a detection assembly configured to receive light from the sensing element;

    an opaque cover layer disposed over a side of the sensing element; and

    a battery in communication with the excitation assembly, wherein all components of the chemical sensor are implanted within the patient;

    communicating data regarding the physiological concentration of the analyte to an implanted pulse generator;

    and altering the delivery of the diuretic therapy to the patient based in part on the physiological concentration of the analyte.

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