Implantable medical device with chemical sensor and related methods
First Claim
1. A method for monitoring diuretic therapy comprising:
- optically sensing a physiological concentration of an analyte in a bodily fluid of a patient with a chronically implanted chemical sensor, the chemical sensor comprising;
a sensing element comprising a potassium ion selective complexing moiety, the potassium ion selective complexing moiety selected from the group comprising cryptands, crown ethers, bis-crown ethers, calixarenes, noncyclic amides, and hemispherands;
an excitation assembly configured to illuminate the sensing element;
a detection assembly configured to receive light from the sensing element;
an opaque cover layer disposed over a side of the sensing element; and
a battery in communication with the excitation assembly, wherein all components of the chemical sensor are implanted within the patient;
communicating data regarding the physiological concentration of the analyte to an implanted pulse generator;
and altering the delivery of the diuretic therapy to the patient based in part on the physiological concentration of the analyte.
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Abstract
In an embodiment, the invention includes an implantable medical device with a pulse generator and a chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid. In an embodiment, the invention includes a method for providing cardiac arrhythmia therapy to a patient including sensing a physiological concentration of an analyte, communicating data regarding the physiological concentration of the analyte to an implanted pulse generator, and delivering therapy to the patient based in part on the physiological concentration of the ion. In an embodiment, the invention includes a method for monitoring diuretic therapy. In an embodiment, the invention includes a method for controlling delivery of an active agent into a human body. Other aspects and embodiments are provided herein.
220 Citations
9 Claims
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1. A method for monitoring diuretic therapy comprising:
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optically sensing a physiological concentration of an analyte in a bodily fluid of a patient with a chronically implanted chemical sensor, the chemical sensor comprising; a sensing element comprising a potassium ion selective complexing moiety, the potassium ion selective complexing moiety selected from the group comprising cryptands, crown ethers, bis-crown ethers, calixarenes, noncyclic amides, and hemispherands;
an excitation assembly configured to illuminate the sensing element;
a detection assembly configured to receive light from the sensing element;
an opaque cover layer disposed over a side of the sensing element; and
a battery in communication with the excitation assembly, wherein all components of the chemical sensor are implanted within the patient;communicating data regarding the physiological concentration of the analyte to an implanted pulse generator; and altering the delivery of the diuretic therapy to the patient based in part on the physiological concentration of the analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification