Implantable micro-electromechanical system sensor

• US 8,127,618 B1
• Filed: 05/18/2007
• Issued: 03/06/2012
• Est. Priority Date: 05/18/2007
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Zhao, Yong D., Dixit, Apratim
• Primary Examiner(s): ALLEN, ANDRE J
• Application Number:
  US11/750,575
• Time in Patent Office: 1,754 Days
• Field of Search: None
• US Class Current: 73/754
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/0271 Thermal or temperature sensors
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371
• CPC Class Codes: G01L 27/002 Calibrating, i.e. establishing true relation between transducer output value and value to be measured, zeroing, linearising or span error determination
• CPC Class Codes: G01L 9/0073 using a semiconductive diaphragm

Abstract

The disclosure relates in some aspects to an implantable pressure sensor and a method of measuring pressure. In some embodiments pressure may be measured through the use of an implantable lead incorporating one or more pressure sensors. In some aspects a pressure sensor is implemented in a micro-electromechanical system (“MEMS”) that employs direct mechanical sensing. A biocompatible material is attached to one or more portions of the MEMS sensor to facilitate implant in a body of a patient. The MEMS sensor may thus be incorporated into an implantable lead for measuring blood pressure in, for example, one or more chambers of the patient'"'"'s heart.

Claims

1. An implantable lead comprising:

a lead body;

a sensor housing attached to the lead body, and defining an internal space, and comprising at least one outer wall defining an aperture;

a micro-electromechanical system (MEMS) pressure sensor comprising a diaphragm, wherein;

the pressure sensor is positioned within the internal space and adjoins the aperture of the sensor housing such that an outer surface of at least a portion of the diaphragm is exposed to the aperture; and

the pressure sensor is sized and contained within the internal space such that during thermal expansion the pressure sensor is free to expand in at least one direction; and

a biocompatible material attached to the outer surface.

2. The implantable lead of claim 1, wherein the biocompatible material is thin and flexible.

3. The implantable lead of claim 1, wherein:

sides of the aperture define side portions of the at least one outer wall; and

the biocompatible material is attached to at least a portion of the side portions.

4. The implantable lead of claim 1, wherein the biocompatible material is attached to at least a portion of an outer surface of the sensor housing.

5. The implantable lead of claim 1, wherein the biocompatible material is attached to at least a portion of an outer surface of the MEMS pressure sensor that does not comprise the diaphragm.

6. The implantable lead of claim 1, wherein the biocompatible material is integrated with the MEMS pressure sensor.

7. The implantable lead of claim 1, wherein the biocompatible material comprises at least one of the group consisting of:

polyimide, ethylene tetrafluoroethylene (ETFE), diamond, carbon, Ti6Al4V, MP35N, platinum, silicon carbide, silicone, polyurethane, gold, parylene, and a metal alloy.

8. The implantable lead of claim 1, wherein the biocompatible material is attached to the outer surface using at least one of the group consisting of:

chemical vapor deposition, dropping, and spraying.

9. The implantable lead of claim 1, further comprising a pliable material positioned between a portion of the MEMS pressure sensor and a portion of the sensor housing.

10. The implantable lead of claim 9, wherein the pliable material is adapted to be more deformable when the pliable material is subjected to temperatures that are above a temperature range at which pressure readings are to be made, as compared to when the pliable material is subjected to temperatures that are within the temperature range at which pressure readings are to be made.

11. The implantable lead of claim 9, wherein the pliable material comprises medical adhesive or epoxy.

12. The implantable lead of claim 1, further comprising a reinforcing material attached to a surface of the MEMS pressure sensor.

13. The implantable lead of claim 1, wherein:

the sensor housing comprises a cover portion welded to a main sensor portion; and

the MEMS pressure sensor is situated between and held in place by the cover portion and the main sensor portion.

14. The implantable lead of claim 1, wherein:

the sensor housing comprises a sensor portion welded to a feed-through portion;

the MEMS pressure sensor is hermetically sealed within the sensor portion;

the lead comprises at least one conductor; and

the feed-through portion defines at least one aperture through which the at least one conductor passes.