Device and method for the dilution and preparation of antiblastic drugs

• US 8,127,804 B2
• Filed: 08/04/2006
• Issued: 03/06/2012
• Est. Priority Date: 03/24/2006
• Status: Active Grant

• Current Assignee: Bioduct S.r.l.
• Original Assignee: Bioduct S.r.l.
• Inventors: Zucca, Giuseppe, Desogus, Michele, Deidda, Maria Cristina
• Primary Examiner(s): HWU, DAVIS D
• Application Number:
  US12/294,106
• Publication Number:
  US 20090165886A1
• Time in Patent Office: 2,041 Days
• Field of Search: 141/9, 141/27, 141/82, 141/94, 141/285.5, 141/309, 435/404, 435/289.1
• US Class Current: 141/9
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

A device and a method for the dilution and preparation of antiballistic drugs, the device comprises a drug preparation unit connected to a controlling device; the drug preparation unit comprises a first central tank, in which there is a solvent, typically a physiological and/or glucosate solution, a first positive-displacement pump, an emptying unit connected to a positioning and locking arrangement provided with a housing suitable for receiving various dimensions and formats of dimensions and formats of bottles of drug; the first positive-displacement pump transfers in a dosed manner the solvent from the central tank to the bottle, and in succession from the bottle to a further tank of semifinished drug; the diluted drug solution in the further tank is then transferred to a container of prepared drug in a determined quantity for infusion into a patient.

Claims

1. Device for the dilution and preparation of antiblastic drugs comprising at least one drug preparation unit provided with a first central tank, said first central tank containing a solvent, a first positive-displacement pump, said first positive-displacement pump comprising a peristaltic pump, an emptying unit for at least one bottle of drug, said first positive-displacement pump being suitable for transferring in a dosed manner said solvent from said central tank to said at least one bottle of drug, said emptying unit comprising a positioning and locking arrangement having a housing suitable for receiving various dimensions and formats of said bottles, wherein said device comprises a further tank for the semi-processed drug, said further tank being filled by said first positive-displacement pump after said at least one bottle of drug, a second positive-displacement pump, said second positive-displacement pump comprising a peristaltic pump, for transferring in a dosed manner the diluted drug from said further tank of the semi-finished drug to a container of prepared drug, wherein said further tank comprises in the upper part an inlet conduit and a hydrophobic filter that enables the tank to be ventilated, filtering particles and microorganisms.

2. Device according to claim 1, wherein said housing is suitable for receiving dimensions and formats of commercially available bottles containing antiblastic drugs.

3. Device according to claim 1, wherein said emptying unit comprises a first unit or replaceable main kit comprising a tip arrangement to be fitted to said bottle of drug, said further tank for the semiprocessed drug and pipes for connecting the various parts.

4. Device according to claim 3, wherein the tip arrangement comprises a tip that comprises in turn a first inlet conduit, a second outlet conduit.

5. Device according to claim 4, wherein the tip arrangement comprises a single-acting nonreturn valve at the inlet to said bottle and a single-acting nonreturn valve at the outlet from said bottle.

6. Device according to claim 1, comprising said container of drug prepared for a patient.

7. Device according to claim 1, comprising an air-dispensing arrangement suitable for delivering compressed air into said bottle of drug.

8. Device according to claim 7, wherein said air-dispensing arrangement comprises a compressor or a positive-displacement pump.

9. Device according to claim 7, wherein said air-dispensing arrangement comprises a filter suitable for filtering the air to be delivered into said bottle of drug.

10. Device according to claim 7, wherein said air-dispensing arrangement comprises a single-acting nonreturn valve that is suitable for permitting a flow of air to said bottle of drug.

11. Device according to claim 7, comprising a flow diverter suitable for diverting the airflow coming from said air-dispensing arrangement in an exclusive and alternative manner to said bottle of drug or to said tank of semifinished drug.

12. Device according to claim 11, comprising an air-supply conduit for said tank of semifinished drug provided with a single-acting nonreturn valve suitable for enabling an airflow to said tank of semifinished drug.

13. Device according to claim 11, comprising a weight-detecting device suitable for detecting the weight of the contents of at least said first central tank, or of said tank of the semifinished drug or of said container of prepared drug.

14. Device according to claim 13, wherein said weight-detecting device is applied to said first central tank, to said tank of the semifinished drug and to said container of prepared drug.

15. Device according to claim 13, wherein said weight-detecting device comprises sensors and a transmitting arrangement for transmitting the signal that is able to detect and transmit the deformation to which they are subjected during weighing operations.

16. Device according to claim 13, wherein said weight-detecting device comprises load cells.

17. Device according to claim 1, comprising a casing that contains at least one drug preparation unit.

18. Device according to claim 17, wherein said casing is provided with a laminar flow hood, so that all the components that are inside said casing are subject to the suction of said vertical laminar flow hood.

19. Device according to claim 1, comprising a controlling device for controlling and managing said at least one drug preparation unit.

20. Device according to claim 19, wherein said controlling device is realised with a programmable device, for example a personal computer, palmtop, etc.

21. Device according to claim 1, comprising a magazine inside which there are said bottles of drug.

22. Device according to claim 21, wherein said magazine comprises a refrigerating zone.

23. Device according to claim 1, comprising a recognising arrangement for identifying and recognising the identifying code of the drug and therefore identifying the information on the drug.

24. Device according to claim 1, wherein said drug preparation unit comprises a dragging mechanism for transferring said bottles.

25. Device according to claim 24, wherein said dragging mechanism comprises a conveyor belt.

26. Device according to claim 1, wherein said further tank comprises a further casing in plastic material that is not transparent to the light and has an asymmetrical and tapered shape towards the bottom.

27. Device according to claim 1, comprising a second unit, or replaceable chemical kit, consisting of said container for the prepared drug.

28. Device according to claim 1, comprising a third unit or replaceable kit container, consisting of said central tank filled with said solvent.