Drug-eluting stent with filament strands

• US 8,128,687 B2
• Filed: 08/25/2006
• Issued: 03/06/2012
• Est. Priority Date: 11/13/2002
• Status: Active Grant

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Rao, K. T. Venkateswara
• Primary Examiner(s): SNOW, BRUCE EDWARD
• Application Number:
  US11/510,431
• Publication Number:
  US 20060287709A1
• Time in Patent Office: 2,020 Days
• Field of Search: 623/1.13, 623/1.22, 623/1.23, 623/1.38, 623/1.39, 623/1.42, 623/1.43
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91508 the meander having a difference in amplitude along the band
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0071 breakable or frangible
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

An intravascular stent having a prefabricated, patterned polymeric sleeve for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel is disclosed. The polymeric sleeve is attached to at least a portion of an outside surface area of the stent structure. Alternatively, a plurality of individual microfilament strands are longitudinally attached to an outer surface of a stent structure in a spaced apart orientation and loaded with at least one therapeutic drug for the release thereof at a treatment site. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. Methods for making the same are also disclosed.

Claims

1. A stent for delivery of a drug in a body lumen, comprising:

a plurality of interconnected struts forming a hollow structure having an interior passageway, the hollow structure including an inner surface facing the interior passageway and an outer surface opposite the inner surface and facing away from the interior passageway; and

a plurality of drug-loaded filament strands attached to the outer surface, each drug-loaded filament strand having a rectangular cross section with a first side, a second side, a third side, and a fourth side, wherein a barrier coating layer is disposed on the first, second and third sides and not disposed on the fourth side to enable drug elution along the fourth side.

2. The stent of claim 1, wherein the drug-loaded filament strands are oriented substantially parallel to each other and distributed in a spaced apart configuration completely around the outer surface of the hollow structure.

3. The stent of claim 1, wherein the drug-loaded filament strands are attached exclusively to the outer surface.

4. The stent of claim 1, wherein the hollow structure is capable of expanding and the drug-loaded filament strands are capable of moving apart from each other when the hollow structure expands.

5. A stent for delivery of a drug in a body lumen, comprising:

a plurality of interconnected struts forming a hollow structure having an interior passageway, the hollow structure including an inner surface facing the interior passageway and an outer surface opposite the inner surface and facing away from the interior passageway; and

a plurality of drug-loaded filament strands, each filament strand attached to the outer surface and including a barrier layer configured to control elution of drug from filament strand,

wherein each filament strand includes multiple layers of polymer, the outermost layer among the multiple layers being the barrier layer, and at least one layer of the multiple layers contains a drug.

6. The stent of claim of claim 5, wherein the plurality of drug-loaded filament strands are not woven about the plurality of interconnected struts.

7. The stent of claim of claim 5, wherein the drug-loaded filament strands are oriented substantially parallel to each other and distributed in a spaced apart configuration completely around the outer surface of the hollow structure.

8. The stent of claim of claim 5, wherein the drug-loaded filament strands are attached exclusively to the outer surface.