Bladder reconstruction
First Claim
1. A method for preparing a device for the replacement or repair of a bladder, or portion of a bladder, in a human comprising:
- a. providing an implantable, biocompatible, synthetic or natural, polymeric matrix structure in the shape of a bladder or portion of a bladder having at least two separate surfaces, wherein the polymeric matrix structure is coated with a biodegradable shape-setting material comprising a liquefied poly-DL-lactide-co-glycolide copolymer;
b. depositing at least a first cell population on or in said polymeric matrix structure to form an organized matrix/cell construct.
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Abstract
The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material.
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Citations
18 Claims
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1. A method for preparing a device for the replacement or repair of a bladder, or portion of a bladder, in a human comprising:
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a. providing an implantable, biocompatible, synthetic or natural, polymeric matrix structure in the shape of a bladder or portion of a bladder having at least two separate surfaces, wherein the polymeric matrix structure is coated with a biodegradable shape-setting material comprising a liquefied poly-DL-lactide-co-glycolide copolymer; b. depositing at least a first cell population on or in said polymeric matrix structure to form an organized matrix/cell construct. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification