Device for separating gas from a liquid path

• US 8,128,740 B2
• Filed: 04/02/2004
• Issued: 03/06/2012
• Est. Priority Date: 04/04/2003
• Status: Active Grant

• Current Assignee: Organ Recovery Systems, Inc. (Shanghai Genext Medical Technology Co., Ltd.)
• Original Assignee: Organ Recovery Systems, Inc. (Shanghai Genext Medical Technology Co., Ltd.)
• Inventors: Garland, Jeffrey C., Wright, David Walter
• Primary Examiner(s): BOWERS, NATHAN ANDREW
• Application Number:
  US10/816,252
• Publication Number:
  US 20040221719A1
• Time in Patent Office: 2,895 Days
• Field of Search: 952/41, 961/55, 961/56, 962/19, 961/82, 961/83, 96/4, 604/319, 435/284.1, 210/436, 210/188, 210/472, 210/422
• US Class Current: 96/155
• CPC Class Codes: A01N 1/02 Preservation of living parts
• CPC Class Codes: A01N 1/0247 for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
• CPC Class Codes: A01N 1/0273 Transport containers A01N1/0268 takes precedence
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters

Abstract

The invention is targeted at the process of separating gas, such as air, from a liquid path. Specifically, the invention provides a means to remove gas from a dynamic liquid path, manage the removed gas and liquid path. The invention provides a means to remove gas from a dynamic liquid path using the buoyant property of gas in a less buoyant liquid, having ingress and egress ports for liquid and gas flow, and separate points of egress for liquid and trapped gas and integral liquid channels.

Claims

1. An apparatus for separating gas from a liquid path, comprising:

a chamber housing defining a chamber capable of holding at least one of liquid and gas, the chamber having a top wall, a bottom wall and side walls, the relative direction of the walls of the chamber being defined when the apparatus is in an at rest position, the chamber comprising;

a first chamber opening in one of the walls configured to allow at least one of gas and liquid to enter the chamber;

a second chamber opening in one of the walls configured to allow at least gas to exit the chamber, the second chamber opening being located in a middle portion in a length of a top portion of the chamber when the apparatus is in the at rest position; and

a third chamber opening in one of the walls configured to allow liquid to exit the chamber, the third chamber opening being located in a middle portion of a bottom portion of the chamber when the apparatus is in the at rest position; and

a plurality of channels being formed within the housing, each of the plurality of channels being in fluid communication with one of the first chamber opening, the second chamber opening and the third chamber opening,

wherein the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings, and

the second and third chamber openings are located relative to one another such that when the apparatus is tilted at any angle up to 70°

in any direction with respect to the at rest position, the second chamber opening remains above the third chamber opening.

2. The apparatus of claim 1, wherein the housing includes at least one connection device, wherein the at least one connection device allows connection with at least one of a tube frame, an organ or tissue transporter, an organ or tissue perfusion apparatus, and an organ or tissue diagnostic device.

3. The apparatus of claim 1, wherein at least a part of the housing is transparent.

4. The apparatus of claim 1, wherein the first chamber opening is located in the bottom portion of the chamber.

5. The apparatus of claim 1, further comprising:

a perfusion circuit connected to the chamber, and a liquid in the perfusion circuit and chamber in a quantity sufficient to fill the chamber to a level that is lower than the second chamber opening when the apparatus is on a level support.

6. The apparatus of claim 1, wherein the housing includes at least first, second and third housing openings.

7. The apparatus of claim 6, wherein the first housing opening is in fluid communication with the first chamber opening, the second housing opening is in fluid communication with the second chamber opening, and the third housing opening is in fluid communication with the third chamber opening.

8. The apparatus of claim 7, wherein the plurality of channels includes an entrance channel having a first end and a second end, wherein the first end is in fluid communication with the first housing opening and the second end is in fluid communication with the first chamber opening.

9. The apparatus of claim 7, wherein the plurality of channels includes an exit channel having a first exit channel end and a second exit channel end, wherein the first exit channel end is in fluid communication with the third chamber opening and the second exit channel end is in fluid communication with the third housing opening.

10. The apparatus of claim 6, wherein tubing is connectible to each of the housing openings to be in fluid communication with the housing openings.

11. The apparatus of claim 10, further comprising a sensor, wherein the sensor is capable of detecting a gas in the tubing connectible to at least one of the first and third housing openings.

12. The apparatus of claim 11, further comprising a flow control valve associated with the third housing opening, wherein the flow control valve prevents liquid from exiting the chamber through tubing connectible to the third housing opening when gas is detected.

13. The apparatus of claim 12, further comprising a flow control valve associated with the tubing connected to the second housing opening, wherein the flow control valve is open when gas is detected to allow gas to leave the chamber.

14. The apparatus of claim 11, wherein the sensor is an ultrasonic sensor.

15. The apparatus of claim 11, further comprising a pump for moving the at least one of liquid and gas through the tubing, wherein the pump stops the flow of the at least one of liquid and gas into the first housing opening when the sensor detects gas in the tubing connectible to the third housing opening.

16. The apparatus of claim 10, wherein the tubing is connectible to at least one of a tube frame, an organ or tissue transporter, an organ or tissue perfusion apparatus, and an organ or tissue diagnostic device.

17. The apparatus of claim 6, further wherein:

one of the plurality of channels extends from the first chamber opening to below the chamber, turns, and connects to the first housing opening at a top portion of the housing.

18. The apparatus of claim 6, wherein one of the plurality of channels extends from the third chamber opening to below the chamber, extends along the bottom wall, turns and extends along one of the side walls, and connects to the third housing opening at a top portion of the housing.

19. The apparatus of claim 6, wherein

a first channel of the plurality of channels extends from the first chamber opening to below the chamber, turns, and connects to the first housing opening at a top portion of the housing, and

a second channel of the plurality of channels extends from the third chamber opening to below the chamber, extends along the bottom wall, turns and extends along one of the side walls, and connects to the third housing opening at a top portion of the housing.

20. An apparatus for separating gas from a liquid path, comprising:

a chamber housing defining a chamber capable of holding at least one of liquid and gas, the chamber having a top wall, a bottom wall and side walls, and the chamber comprising;

a first chamber opening in one of the walls configured to allow at least one of gas and liquid to enter the chamber;

a second chamber opening in one of the walls configured to allow at least gas to exit the chamber, the second chamber opening being located in a middle portion in a length of a top portion of the chamber; and

a third chamber opening in one of the walls configured to allow liquid to exit the chamber, the third chamber opening being located in a middle portion of a bottom portion of the chamber; and

a plurality of channels being formed within the housing, each of the plurality of channels being in fluid communication with one of the first chamber opening, the second chamber opening and the third chamber opening, wherein;

the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings,

the housing includes at least first, second and third housing openings,

the first housing opening is in fluid communication with the first chamber opening, the second housing opening is in fluid communication with the second chamber opening, and the third housing opening is in fluid communication with the third chamber opening, and

the first and third housing openings are located on a same side wall of the housing.

21. The apparatus of claim 20, wherein the first and third housing openings are located at opposite ends of the same side wall.

22. The apparatus of claim 21, wherein the second housing opening is located on the same side wall substantially midway between the first and third openings.

23. The apparatus of claim 22, wherein the first, second and third housing openings are located at or near a top of the same side wall.

24. The apparatus of claim 23, wherein the first, second and third housing openings are oriented substantially on the same plane.

25. The apparatus of claim 20, further comprising a sensor, wherein tubing is connectible to each of the housing openings to be in fluid communication with the housing openings and the sensor is capable of detecting a gas in the tubing connectible to at least one of the first and third housing openings.

26. An apparatus for separating gas from a liquid path, comprising:

a chamber housing defining a chamber capable of holding at least one of liquid and gas, the chamber having a top wall, a bottom wall and side walls, and the chamber comprising;

a first chamber opening in one of the walls configured to allow at least one of gas and liquid to enter the chamber;

a second chamber opening in one of the walls configured to allow at least gas to exit the chamber, the second chamber opening being located in a middle portion in a length of a top portion of the chamber; and

a third chamber opening in one of the walls configured to allow liquid to exit the chamber, the third chamber opening being located in a middle portion of a bottom portion of the chamber; and

a plurality of channels being formed within the housing, each of the plurality of channels being in fluid communication with one of the first chamber opening, the second chamber opening and the third chamber opening, wherein;

the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings,

the housing includes at least first, second and third housing openings,

the first housing opening is in fluid communication with the first chamber opening, the second housing opening is in fluid communication with the second chamber opening, and the third housing opening is in fluid communication with the third chamber opening,

the plurality of channels includes an entrance channel having a first end and a second end, wherein the first end is in fluid communication with the first housing opening and the second end is in fluid communication with the first chamber opening, and

the first housing opening is located at or near the top portion of the housing and the first chamber opening is at or near the bottom portion of the chamber.

27. The apparatus of claim 26, wherein at least a portion of the entrance channel is approximately vertical.

28. The apparatus of claim 27, wherein the approximately vertical portion of the channel extends approximately a height of the chamber.

29. The apparatus of claim 27, wherein at least a portion of the entrance channel near the second end is curved.

30. The apparatus of claim 26, further comprising a sensor, wherein tubing is connectible to each of the housing openings to be in fluid communication with the housing openings and the sensor is capable of detecting a gas in the tubing connectible to at least one of the first and third housing openings.

31. An apparatus for separating gas from a liquid path, comprising:

a chamber housing defining a chamber capable of holding at least one of liquid and gas, the chamber having a top wall, a bottom wall and side walls, and the chamber comprising;

a first chamber opening in one of the walls configured to allow at least one of gas and liquid to enter the chamber;

a second chamber opening in one of the walls configured to allow at least gas to exit the chamber, the second chamber opening being located in a middle portion in a length of a top portion of the chamber;

a third chamber opening in one of the walls configured to allow liquid to exit the chamber, the third chamber opening being located in a middle portion of a bottom portion of the chamber; and

a plurality of channels being formed within the housing, each of the plurality of channels being in fluid communication with one of the first chamber opening, the second chamber opening and the third chamber opening, wherein;

the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings,

the housing includes at least first, second and third housing openings,

the first housing opening is in fluid communication with the first chamber opening, the second housing opening is in fluid communication with the second chamber opening, and the third housing opening is in fluid communication with the third chamber opening,

the plurality of channels includes an exit channel having a first exit channel end and a second exit channel end, wherein the first exit channel end is in fluid communication with the third chamber opening and the second exit channel end is in fluid communication with the third housing opening, and

at least a portion of the exit channel is approximately horizontal and the third chamber opening is in fluid communication with the approximately horizontal portion of the exit channel by the first end of the exit channel.

32. The apparatus of claim 31, wherein at least a portion of the exit channel is approximately vertical and one end of the approximately vertical portion is in fluid communication with the approximately horizontal portion and another end of the substantially vertical portion is in fluid communication with the third housing opening.

33. The apparatus of claim 32, wherein the approximately vertical and horizontal portions are connected by a curved portion of the exit channel.

34. The apparatus of claim 31, wherein the approximately horizontal portion of the exit channel extends approximately the length of the bottom wall of the chamber.

35. The apparatus of claim 32, wherein the approximately vertical portion of the exit channel extends approximately the height of a side wall of the chamber.

36. The apparatus of claim 31, further comprising a sensor, wherein tubing is connectible to each of the housing openings to be in fluid communication with the housing openings and the sensor is capable of detecting a gas in the tubing connectible to at least one of the first and third housing openings.

37. An apparatus for separating gas from a liquid path, comprising:

a chamber housing defining a chamber capable of holding at least one of liquid and gas, the chamber having a top wall, a bottom wall and side walls, and the chamber comprising;

a first chamber opening in one of the walls configured to allow at least one of gas and liquid to enter the chamber;

a second chamber opening in one of the walls configured to allow at least gas to exit the chamber, the second chamber opening being located in a middle portion in a length of a top portion of the chamber; and

a third chamber opening in one of the walls configured to allow liquid to exit the chamber, the third chamber opening being located in a middle portion of a bottom portion of the chamber; and

a plurality of channels being formed within the housing, each of the plurality of channels being in fluid communication with one of the first chamber opening, the second chamber opening and the third chamber opening, wherein

the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings,

the housing includes at least first, second and third housing openings,

the first housing opening is in fluid communication with the first chamber opening, the second housing opening is in fluid communication with the second chamber opening, and the third housing opening is in fluid communication with the third chamber opening, and

the plurality of channels includes;

an entrance channel having a first end and a second end, wherein the first end is in fluid communication with the first housing opening located at or near a top portion of the housing and the second end is in fluid communication with the first chamber opening located at or near the bottom of the chamber, wherein at least a portion of the entrance channel is approximately vertical and extends approximately a height of the chamber and at least a portion of the entrance channel near the second end is curved; and

an exit channel having a first exit channel end and a second exit channel end, wherein the first exit channel end is in fluid communication with the third chamber opening and the second exit channel end is in fluid communication with the third housing opening, wherein at least a portion of the exit channel is approximately horizontal and the third chamber opening is in fluid communication with the approximately horizontal portion of the exit channel by the first end of the exit channel, at least a portion of the exit channel is approximately vertical and one end of the approximately vertical portion is in fluid communication with the approximately horizontal portion and another end of the substantially vertical portion is in fluid communication with the third housing opening, the approximately vertical and horizontal portions are connected by a curved portion of the exit channel, wherein the approximately horizontal portion of the exit channel extends approximately ½

the length of the bottom wall of the chamber and the approximately vertical portion of the exit channel extends approximately the height of a side wall of the chamber.

38. The apparatus of claim 37, further comprising a sensor, wherein tubing is connectible to each of the housing openings to be in fluid communication with the housing openings and the sensor is capable of detecting a gas in the tubing connectible to at least one of the first and third housing openings.

39. A method for separating gas from a liquid path in a chamber housing that defines a chamber capable of holding at least one of liquid and gas, the chamber including a top wall, a bottom wall, and side walls, the relative direction of the walls of the chamber being defined when the apparatus is in an at rest position, the method comprising:

supplying at least one of liquid and gas to the chamber through a first chamber opening in one of the walls;

removing gas from the chamber through a second chamber opening in one of the walls, the second chamber opening being located in a middle portion in a length of a top portion of the chamber when the apparatus is in the at rest position;

removing liquid from the chamber through a third chamber opening in one of the walls, the third chamber opening being located in a middle portion of a bottom portion of the chamber when the apparatus is in the at rest position, maintaining enough liquid in the chamber that when the chamber is tilted at an angle up to approximately 90 degrees, only liquid leaves the chamber through the third chamber opening,

wherein each of the chamber openings is in fluid communication with one of a plurality of channels formed within the chamber housing,

the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings, and

the second and third chamber openings are located relative to one another such that when the apparatus is tilted at any angle up to 70°

in any direction with respect to the at rest position, the second chamber opening remains above the third chamber opening.

40. The method of claim 39, wherein the chamber is structured to allow uninhibited fluid communication between the first chamber opening, the second chamber opening and the chamber third chamber opening.

41. The method of claim 40,

wherein the plurality of channels includes an entrance channel having a first end and a second end, the entrance channel connecting the first chamber opening with a first housing opening in the housing, and

wherein the first end is connected to the first housing opening and the second end is connected to the first chamber opening.

42. The method of claim 40,

wherein the plurality of channels includes an exit channel having a first end and a second end, the exit channel connecting the third chamber opening with a third housing opening, and

wherein the first exit channel end is connected to the third chamber opening and the second exit channel end is connected to a third housing opening.

43. The method of claim 42, wherein the second chamber opening is connected to a second housing opening.

44. The method of claim 43, wherein the first, second, and third housing openings are located on a same wall of the housing.

45. The method of claim 44, wherein the first, second, and third housing openings are oriented on substantially the same plane.

46. The method of claim 40, further comprising connecting the housing to at least one of a tube frame, an organ or tissue transporter, an organ or tissue perfusion apparatus, and an organ or tissue diagnostic device.

47. The method of claim 40, further comprising connecting tubing to at least one of first, second, and third housing openings.

48. The method of claim 47, further comprising detecting gas in at least one of the tubing connected to the first and third housing openings.

49. The method of claim 48, further comprising closing a flow control valve associated with the third housing opening when gas is detected, thereby effectively preventing liquid from exiting the housing through the tubing connected to the third housing opening.

50. The method of claim 49, further comprising opening a flow control valve associated with the tubing connected to the second housing opening when the flow control valve associated with the third housing opening is closed, thereby effectively removing gas from the chamber.

51. The method of claim 50, wherein the opening and closing of the flow control valves occurs at preset time intervals.

52. The method of claim 51, wherein the gas in the tubing is detected by a sensor.

53. The method of claim 52, further comprising opening and closing the flow control valves as a result of a signal sent by the sensor.

56. The method of claim 47, further comprising connecting the tubing to at least one of a tube frame, an organ or tissue transporter, an organ or tissue perfusion apparatus, and an organ or tissue diagnostic device.

57. The method of claim 40, further comprising forming the housing by mating a plurality of sections.

58. The method of claim 57, further comprising melting an energy director to hermetically seal the sections.

59. The method of claim 58, wherein the energy director is melted by ultrasonic welding.

54. The method of 52, wherein the sensor is an ultrasonic sensor.

55. The method of 48, further comprising stopping the flow of the at least one of liquid and gas into the first housing opening when gas is detected is the tubing connected to the third housing opening.

60. An apparatus for transporting an organ or tissue, comprising:

an organ or tissue transporter;

a chamber housing defining a chamber capable of holding at least one of liquid and gas, the chamber housing connectible to the organ transporter, the chamber having a top wall, a bottom wall and side walls capable of holding at least one of liquid and gas and the relative direction of the walls of the chamber being defined when the apparatus is in an at rest position, the chamber comprising;

a first chamber opening in one of the walls configured to allow at least one of gas and liquid to enter the chamber;

a second chamber opening in one of the walls configured to allow at least gas to exit the chamber, the second chamber opening being located in a middle portion in a length of a top portion of the chamber when the apparatus is in the at rest position; and

a third chamber opening in one of the walls configured to allow liquid to exit the chamber, the third chamber opening being located in a middle portion of a bottom portion of the chamber when the apparatus is in the at rest position; and

a plurality of channels being formed within the housing, each of the plurality of channels being in fluid communication with one of the first chamber opening, the second chamber opening and the third chamber opening,

wherein the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings, and

the second and third chamber openings are located relative to one another such that when the apparatus is tilted at any angle up to 70°

in any direction with respect to the at rest position, the second chamber opening remains above the third chamber opening.

61. The apparatus of claim 60, wherein

the housing includes at least one connection device connectible to the organ transporter, and

the chamber is structured to allow uninhibited fluid communication between the first chamber opening, the second chamber opening and the third chamber opening.

62. The apparatus of claim 61, wherein the housing includes at least first, second and third housing openings and tubing that is connectible to each of the first, second, and third housing openings.

63. The apparatus of claim 62, further comprising a sensor, wherein the sensor is capable of detecting a gas in the tubing.

64. The apparatus of claim 63, further comprising a flow control valve connectible to the organ transporter and associated with the tubing connectible to the third housing opening, wherein the flow control valve prevents liquid from exiting the chamber through tubing connectible to the third housing opening when gas is detected.

65. The apparatus of claim 63, further comprising a flow control valve connectible to the organ transporter and associated with the tubing connectible to the second housing opening, wherein the flow control valve is open when gas is detected to allow gas to leave the chamber.

66. The apparatus of claim 63, wherein the sensor is an ultrasonic sensor.

67. The apparatus of claim 63, further comprising a pump connectible to the organ transporter for moving the at least one of liquid and gas through the tubing, wherein the pump stops the flow of the at least one of liquid and gas into the first housing opening when the sensor detects gas in the tubing connectible to the third housing opening.

68. The apparatus of claim 62, wherein the housing and the tubing are connectible to a tube frame capable of holding at least a plurality of tubes, wherein the tube frame is connectible to the organ transporter.

69. The apparatus of claim 60, wherein the first chamber opening is located in the lower portion of the chamber.

70. The apparatus of claim 60, further comprising a sensor, wherein tubing is connectible to each of the channels to be in fluid communication with the chamber openings and the sensor is capable of detecting a gas in the tubing connectible to at least one of the channels.

71. An apparatus for separating gas from a liquid path, comprising:

a chamber housing defining a chamber having a bottom, a top and side walls, the chamber housing being capable of holding at least one of liquid and gas;

a first chamber opening configured to allow at least one of gas and liquid to enter the chamber;

a second chamber opening configured to allow at least gas to exit the chamber;

a third chamber opening configured to allow liquid to exit the chamber;

a liquid at a level that is below the second chamber opening and above the third chamber opening when the apparatus is in an at rest position and when the apparatus is tilted at any angle up to 70°

in any direction from the at rest position, wherein

the first chamber opening is in one of the side walls,

the second chamber opening is in one of the side walls and located in a middle portion in a length of an upper portion of the chamber,

the third chamber opening is in one of the side walls and located in a middle portion of a lower portion of the chamber,

a plurality of channels are formed within the housing, each of the plurality of channels being in fluid eon communication with one of the first chamber opening, the second chamber opening and the third chamber opening, and

the chamber is structured to allow uninhibited fluid communication between the first, second and third chamber openings.

72. The apparatus of claim 71, further comprising a sensor, wherein tubing is connectible to each of the channels to be in fluid communication with the chamber openings and the sensor is capable of detecting a gas in the tubing connectible to at least one of the channels.