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Automated system for continuously and automatically calibrating electrochemical sensors

  • US 8,128,801 B2
  • Filed: 10/27/2005
  • Issued: 03/06/2012
  • Est. Priority Date: 08/22/2001
  • Status: Active Grant
First Claim
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1. A method for monitoring sensor system performance for in vitro diagnostic testing of patient samples, comprising:

  • (a) providing a plurality of sensors and one or more internal reference solutions in a replaceable cartridge for use in a sensor system, said internal reference solutions comprising a plurality of analytes each having a known concentration;

    (b) determining a first response of one sensor of the plurality of sensors to one of the plurality of analytes in a first internal reference solution in between testing of patient samples;

    (c) determining a second response of the one sensor of the plurality of sensors to the one of the plurality of analytes in the first internal reference solution;

    (d) taking action in response to the determining in steps (b) and (c) to provide continued testing of patient samples by initiating a cleaning cycle if the first response to the analyte in step (b) is substantially similar to the second response to the analyte in step (c) and the first and the second responses are substantially dissimilar to the response of the sensor to the known concentration of the analyte;

    (e) optionally signaling for replacement of said cartridge when the action of step (d) fails to provide continued testing of patient samples.

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