Platelet preservation composition comprising a short to ultra-short acting antiplatelet agent and anticoagulant with hemoglobin
First Claim
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1. A platelet preservation composition, comprising:
- a) a short-to-ultra-short acting antiplatelet agent;
b) a short-to-ultra-short acting anticoagulant; and
c) a hemoglobin-based oxygen carrier;
wherein said composition is capable of extending the shelf-life of a platelet.
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Abstract
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
22 Citations
18 Claims
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1. A platelet preservation composition, comprising:
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a) a short-to-ultra-short acting antiplatelet agent; b) a short-to-ultra-short acting anticoagulant; and c) a hemoglobin-based oxygen carrier;
wherein said composition is capable of extending the shelf-life of a platelet. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification