Selective enzymatic esterification and solvolysis of epimeric vitamin D analog and separation of the epimers
First Claim
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1. A method of selectively enzymatically esterifying the C-24 hydroxyl group of one epimer in a mixture of C-24 epimers of a compound of general formula III or IX:
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Abstract
Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The metod can be used, for example, for separating mixed epimers of the vitamin D analog.
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Citations
24 Claims
- 1. A method of selectively enzymatically esterifying the C-24 hydroxyl group of one epimer in a mixture of C-24 epimers of a compound of general formula III or IX:
- 16. A method of selectively enzymatically esterifying the C-24 hydroxyl group of one epimer in a mixture of C-24 epimers of a compound of general formula III or IX
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