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Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production

  • US 8,129,182 B2
  • Filed: 03/02/2007
  • Issued: 03/06/2012
  • Est. Priority Date: 03/02/2006
  • Status: Active Grant
First Claim
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1. An in vitro cell culture comprising human cells differentiated from human pluripotent stem cells, wherein at least 5% of said human cells are endocrine precursor cells that express neurogenin 3 (NEUROG3), paired box 4 (PAX4) and NKX2 transcription factor related locus 2 (NKX2.2), said endocrine precursor cells being multipotent cells that can differentiate into pancreatic islet hormone-expressing cells that express at least one pancreatic hormone selected from the group consisting of insulin, somatostatin, ghrelin, pancreatic polypeptide and glucagon.

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