Multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration

• US 8,129,699 B2
• Filed: 05/12/2009
• Issued: 03/06/2012
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): MASKELL, MICHAEL P
• Application Number:
  US12/464,816
• Publication Number:
  US 20090309046A1
• Time in Patent Office: 1,029 Days
• Field of Search: 250/492.1, 250/492.3, 250/396.R, 313/62, 315/503, 315/504
• US Class Current: 250/492.3
• CPC Class Codes: A61N 2005/1059 using cameras imaging the patient
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: H05H 13/04 Synchrotrons

Abstract

The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field imaging and/or a multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration via use of feedback sensors used to monitor and/or control patient respiration. Preferably, the multi-field imaging, such as X-ray imaging, and the charged particle therapy are performed on a patient in a partially immobilized and repositionable position. X-ray and/or proton delivery is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Claims

1. An apparatus using charged particles for irradiation of a tumor of a patient, comprising:

a synchrotron comprising multi-axis control, said multi-axis control comprising control of;

an energy; and

an intensity; and

a rotatable platform,

wherein said control of said energy and said control of said intensity occurs during extraction,

wherein said rotatable platform rotates through about three hundred sixty degrees during an irradiation period,

wherein said multi-axis control operates during at least ten rotation positions of said rotatable platform.

2. The apparatus of claim 1, further comprising:

a respiration sensor generating a respiration signal, said respiration signal corresponding to a breathing cycle of the patient, wherein timing control uses said respiration signal to time delivery of the charged particles with a set point in said breathing cycle.

3. The apparatus of claim 2, wherein said multi-axis control further comprises independent control of all of:

a horizontal position of the charged particles;

a vertical position of the charged particles;

said energy; and

said intensity, wherein said multi-axis control comprises delivery of the charged particles at said set point in the breathing cycle and in coordination with rotation of the patient on said rotatable platform during said at least ten rotation positions of said rotatable platform.

4. The apparatus of claim 1, said synchrotron further comprising:

an acceleration period accelerating the charged particles; and

an extraction foil, wherein timing of the charged particles striking said extraction foil in said acceleration period results in extraction at said energy.

5. The apparatus of claim 4, further comprising:

a current resulting from the charged particles striking said extraction foil, said current used as a feedback control to a radio-frequency cavity system, wherein an applied radio frequency, using said feedback control, in said radio-frequency cavity system results in said control of said intensity.

6. The apparatus of claim 5, wherein said multi-axis control further comprises separate control of all of:

an x-axis position of the charged particles;

a y-axis position of the charged particles;

said energy; and

said intensity, wherein said multi-axis control comprises delivery of the charged particles at a set point in a breathing cycle of the patient at at least five rotation positions of a rotatable platform holding the patient.

7. The apparatus of claim 1, wherein said synchrotron further comprises:

a beam extraction path, said path sequentially comprising;

a radio-frequency cavity system comprising a first pair of blades;

a foil, said foil comprising a thickness of about thirty to one-hundred microns, said foil consisting essentially of atoms having six or fewer protons;

a second pair of blades; and

an extraction magnet.

8. The apparatus of claim 1, wherein said control of said energy further comprises control of an accelerator system in said synchrotron, said accelerator system comprising:

a set of at least ten coils;

a set of at least ten wire loops;

a set of at least ten microcircuits, each of said microcircuits integrated to one of said loops, wherein each of said loops completes at least one turn about at least one of said coils; and

a radio-frequency synthesizer sending a low voltage signal to each of said microcircuits, each of said microcircuits amplifying said low voltage signal yielding an acceleration voltage.

9. The apparatus of claim 1, wherein said multi-axis control increases said intensity when targeting a distal portion of the tumor, wherein said distal portion of said tumor changes with rotation of the patient on a platform rotating to as least ten distinct rotational positions in a period of less than one minute during irradiation of the tumor by the charged particles.

10. The apparatus of claim 1, wherein said multi-axis control further comprises:

horizontal position control of the charged particles;

vertical position control of the charged particles; and

an X-ray input signal, wherein said X-ray input signal comprises a signal generated by an X-ray source proximate the charged particle beam,

wherein said X-ray input signal is used in;

setting position of said horizontal position and setting position of said vertical position.

11. A method for controlling charged particles, the charged particles used to irradiate a tumor of a patient, comprising the steps of:

extracting the charged particles from a synchrotron; and

controlling the charged particles along multi-axis, said multi-axis comprising;

an energy; and

an intensity,

wherein said step of controlling said energy and said step of controlling said intensity both occur prior to the charged particles passing through a Lamberson extraction magnet in said synchrotron during said step of extracting.

12. The method of claim 11, further comprising the step of:

during said step of extracting, separately controlling each of said energy and said intensity.

13. The method of claim 11, further comprising the step of:

timing both said step of controlling said energy and said step of controlling said intensity to position of the patient.

14. The method of claim 13, further comprising the step of:

rotating a rotatable platform through about three hundred sixty degrees during an irradiation period,

wherein said step of controlling said step of extracting both operate during at least ten rotation positions of said rotatable platform.

15. The method of claim 14, further comprising the steps of:

holding the patient with said rotatable platform;

delivering the charged particles to the tumor of the patient from said synchrotron during said step of rotating the patient on said rotatable platform; and

distributing ingress energy of the charged particles to at least ten areas about the tumor.

16. The method of claim 14, further comprising the step of:

generating a respiration signal with a respiration sensor, said respiration signal corresponding to a breathing cycle of the patient, wherein said step of timing uses said respiration signal to time delivery of the charged particles to the tumor at a set point in said breathing cycle.

17. The method of claim 16, further comprising the steps of:

independently controlling said multi-axis, wherein said multi-axis further comprises;

a horizontal position of the charged particles; and

a vertical position of the charged particles, and

delivering the charged particles at said set point in the breathing cycle and in coordination with said step of rotating during at least ten rotation positions of said rotatable platform.

18. The method of claim 11, further comprising the steps of:

accelerating the charged particles during an acceleration period of said synchrotron; and

timing extraction of the charged particles striking an extraction foil to yield said energy.

19. The method of claim 18, further comprising the steps of:

striking said extraction foil with the charged particles to yield a current;

using said current as a feedback control to a radio-frequency cavity system; and

controlling said intensity by applying a radio frequency in said feedback control to said radio-frequency cavity system.