Apparatus and method for estimating stroke volume of the heart using bio-impedance techniques

• US 8,131,354 B2
• Filed: 12/27/2004
• Issued: 03/06/2012
• Est. Priority Date: 07/03/2002
• Status: Expired due to Fees

• Current Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Original Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Inventors: Arad (Abboud), Shimon
• Primary Examiner(s): Smith, Ruth S
• Application Number:
  US11/023,912
• Publication Number:
  US 20050107719A1
• Time in Patent Office: 2,626 Days
• Field of Search: 600/428, 600/509, 600/513, 600/526, 600/547, 702/19, 702/57, 702/65
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0044 for the heart
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/7289 Retrospective gating, i.e. associating measured signals or images with a physiological event after the actual measurement or image acquisition, e.g. by simultaneously recording an additional physiological signal during the measurement or image acquisition
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal

Abstract

A method of estimating stroke volume of the heart is described. In this method, the volume of the heart is estimated from electrical impedance data of the chest, at two different phases of the cardiac cycle. The stroke volume is estimated from the difference between the volumes estimated at the two phases.

Claims

1. A method of estimating stroke volume of the heart, comprising:

acquiring a first set of electrical data of the chest, using electrodes placed on skin around the chest, at a first phase of the cardiac cycle;

estimating a first volume of the heart from the first set of electrical data;

acquiring a second set of electrical data of the chest, using electrodes placed on skin around the chest, at a second phase of the cardiac cycle;

estimating a second volume of the heart from the second set of electrical data; and

using the difference between the first and second volumes of the heart to estimate the stroke volume of the heart;

wherein estimating the first volume of the heart comprises generating a first impedance image of the chest from the first set of electrical data, and estimating the second volume of the heart comprises generating a second impedance image of the chest from the second set of electrical data, and generating the second impedance image of the chest comprises putting constraints on differences between the second impedance image and the first impedance image, but not constraining the volume of the heart to be the same in the first and second impedance images.

2. A method according to any claim 1, wherein one of the first and second phases of the cardiac cycle comprises an end-systole phase.

3. A method according to claim 1, wherein one of the first and second phases of the cardiac cycle comprises an end-diastole phase.

4. A method according to claim 1, wherein, for each of said phases of the cardiac cycle, generating the impedance image comprises generating a two-dimensional impedance image of a slice of the chest, and estimating the volume of the heart comprises estimating a cross-sectional area of the interior of the heart.

5. A method according to claim 4, wherein generating the impedance image comprises modeling the cross-sectional area of the interior of the heart as an ellipse.

6. A method according to claim 4, wherein estimating the volume of the heart comprises modeling the cross-sectional area of the interior of the heart as an ellipse.

7. A method according to claim 4, wherein estimating the volume of the heart comprising using a formula which gives the volume of the heart as a function of the cross-sectional area.

8. A method according to claim 7, wherein the volume is proportional to the square of the cross-sectional area.

9. A method according to claim 1, wherein the second impedance image, aside from the heart, is constrained to be the same as the first impedance image.

10. A method according to claim 1, wherein acquiring electrical data of the chest comprises measuring potential differences between one or more pairs among a plurality of voltage-measuring locations on the body, while applying known currents at a plurality of current-applying locations on the body.

11. A method according to claim 10, wherein applying known currents comprises applying a current between a first pair of current-applying locations at substantially opposite sides of the chest.

12. A method according to claim 11, wherein applying known currents is done a second time, using a second pair of current-applying locations that are substantially on opposite sides of the chest and differ from the first pair of current-applying locations.

13. A method according to claim 12, wherein each of the pairs of current-applying locations comprises a location on the left side of the front of the chest, and a location on the right side of the back.

14. A method according to claim 12, wherein, for each time the known currents are applied, the plurality of voltage-measuring locations comprises three different locations, at least two of them on the front of the chest, and all three of them different from either of the pair of current-carrying locations at which the known currents are being applied at that time.

15. A method according to claim 1, wherein estimating the first volume of the heart comprises generating a first impedance image of the chest from the first set of electrical data, using a finite volume method, and estimating the second volume of the heart comprises generating a second impedance image of the chest from the second set of electrical data, using a finite volume method.

16. A method according to claim 1, wherein acquiring the first set of electrical data, and acquiring the second set of electrical data, each comprise using four, five, six, seven or eight electrodes placed on skin around the chest.

17. An apparatus for estimating the stroke volume of the heart, comprising:

an electrocardiograph;

an impedance imaging data acquisition system which acquires impedance data of the chest;

a controller which uses data from the electrocardiograph to trigger the data acquisition system to acquire the impedance data at each of a first phase and a second phase of the cardiac cycle; and

a data analyzer which reconstructs a first impedance image of the chest at the first phase and a second impedance image of the chest at the second phase, from the data acquired at the first phase and the second phase, and estimates the volume of the heart in each of the impedance images, thereby allowing the stroke volume to be estimated from the difference between the volume of the heart at the first phase and the second phase;

wherein the data analyzer reconstructs the second impedance image of the chest by putting constraints on differences between the second impedance image and the first impedance image, but not constraining the volume of the heart to be the same in the first and second impedance images.

18. An apparatus according to claim 17, wherein the data analyzer is configured to analyze the electrocardiograph data to obtain information about breathing parameters at the time the impedance imaging data was acquired, and is configured to use the information about breathing parameters in estimating the volume of the heart at the first phase and the second phase, thereby making the estimate of the stroke volume more accurate.

19. An apparatus according to claim 17, wherein the electrocardiograph, impedance data acquisition system, and controller comprise a self-contained portable system weighing less than 5 kilograms.

20. An apparatus according to claim 17, including a user interface to the controller whereby the user initiates a pre-set sequence of acquisition of the impedance data, the time of the acquisition being triggered by data from the electrocardiograph.