Potentiostat circuit

• US 8,133,369 B2
• Filed: 02/08/2008
• Issued: 03/13/2012
• Est. Priority Date: 02/09/2007
• Status: Active Grant

• Current Assignee: Seiko Epson Corporation (Seiko Group)
• Original Assignee: Seiko Epson Corporation (Seiko Group)
• Inventors: Tam, Simon
• Primary Examiner(s): Barton, Jeffrey T
• Assistant Examiner(s): DIETERLE, JENNIFER M
• Application Number:
  US12/068,634
• Publication Number:
  US 20080223719A1
• Time in Patent Office: 1,495 Days
• Field of Search: 204/406, 204/400, 204/403.01, 204/412, 324691-724
• US Class Current: 204/406
• CPC Class Codes: G01N 27/3277 being a redox reaction, e.g. detection by cyclic voltammetry voltammetry per se G01N27/42, G01N27/48

Abstract

A potentiostat is provided for a biosensor circuit and permits sequential and simultaneous measurements to be performed at different cells across a matrix of biosensing devices. Accordingly, a potentiostat comprises a first differential amplifier for receiving a scanning voltage at a first input terminal and a voltage at the reference electrode at a second input terminal and for generating an output voltage at an output terminal to be applied to the working electrode, wherein, when in use, a feedback loop of the potentiostat circuit is closed between the reference electrode and the working electrode.

Claims

1. A biosensor circuit comprising a counter electrode, a reference electrode, a working electrode and a potentiostat circuit, the potentiostat circuit, comprising:

a first differential amplifier that receives a scanning voltage at a first input terminal and the voltage of the reference electrode at a second input terminal, and generate an output voltage at an output terminal applied to the working electrode, a feedback loop of the potentiostat circuit being closed between the reference electrode and the working electrode;

a first operational amplifier;

the output voltage of the first differential amplifier being applied to a first input terminal of the first operational amplifier, which has a negative feedback between an output terminal and a second input terminal, and the working electrode being connected to the second input terminal of the first operational amplifier and held at the voltage of the first input terminal of the first operational amplifier; and

a second differential amplifier having a first input terminal connected to the output terminal of the first operational amplifier and a second input terminal connected to the first input terminal of the first operational amplifier.

2. The biosensor circuit according to claim 1, the first input terminal of the first operational amplifier being a non-inverting input terminal and the second input terminal of the first operational amplifier being an inverting input terminal.

3. The biosensor circuit according to claim 1,

the first input terminal of the second differential amplifier being an inverting input terminal;

and

the second input terminal of the second differential amplifier being a non-inverting input terminal.

4. The biosensor circuit according to claim 1, further comprising:

a second operational amplifier having a first input terminal connected to the reference electrode; and

an output terminal connected to the second input terminal of the first differential amplifier.

5. The biosensor circuit according to claim 1, wherein the biosensor circuit is a single-channel biosensor circuit.

6. A multi-channel biosensor circuit including the biosensor circuit according to claim 1, further comprising:

an array of counter electrodes, reference electrodes and working electrodes, each reference electrode in the array of reference electrodes being connected to a respective first terminal of a first switch; and

each working electrode in the array of working electrodes being connected to a respective first terminal of a second switch,

the first switch and the second switch each having a second terminal being connected to the potentiostat circuit, wherein

outputs of a shift register unit are connected to a gate terminal of each respective first switch and each respective second switch and thereby adapted to select a counter electrode, reference electrode and working electrode in the array for sequential readout by the potentiostat circuit.

7. A multi-channel biosensor circuit, comprising:

an array of the single-channel biosensor circuits according to claim 5, each biosensor circuit of the array of the single-channel biosensor circuits being configured to read out simultaneously.

8. The multi-channel biosensor circuit according to claim 7, an input line being shared by each respective first differential amplifier of each respective potentiostat circuit for receiving the scanning voltage.

9. The multi-channel biosensor circuit according to claim 7, each first differential amplifier of each respective potentiostat circuit being connected to a respective input line for receiving the scanning voltage.