Calcium phosphate complex in acid containing chewing gum

• US 8,133,475 B2
• Filed: 04/04/2007
• Issued: 03/13/2012
• Est. Priority Date: 04/05/2006
• Status: Active Grant

• Current Assignee: Perfetti Van Melle Benelux BV (Perfetti Van Melle S.P.A.)
• Original Assignee: Cadbury Adams USA LLC (Mondelez International, Inc.)
• Inventors: Tancredi, Doris, Ming, Ding, Holme, Samantha
• Primary Examiner(s): Kishore, Gollamudi
• Assistant Examiner(s): Maewall, Snigdha
• Application Number:
  US11/732,803
• Publication Number:
  US 20070237805A1
• Time in Patent Office: 1,805 Days
• Field of Search: 424/48
• US Class Current: 424/48
• CPC Class Codes: A23G 3/36 characterised by the composition containing organic or inorganic compounds
• CPC Class Codes: A23G 3/362 containing inorganic compounds
• CPC Class Codes: A23G 3/44 containing peptides or proteins containing dairy products A23G3/46
• CPC Class Codes: A23G 4/06 characterised by the composition containing organic or inorganic compounds
• CPC Class Codes: A23G 4/064 containing inorganic compounds
• CPC Class Codes: A23G 4/14 containing peptides or proteins containing dairy products A23G4/16
• CPC Class Codes: A23L 33/165 Complexes or chelates
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/08 Food product presented as a kit of parts
• CPC Class Codes: A23V 2200/312 having an effect on dental health
• CPC Class Codes: A23V 2250/1578 Calcium
• CPC Class Codes: A23V 2250/54246 Casein
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/362 Polycarboxylic acids
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The present invention relates to chewing gum and confectionery compositions for improving the dental health of mammals, particularly humans. In particular, the compositions may include a gum base or carrier, sweetening agents, casein phosphopeptide-calcium phosphate (CPP-ACP) and food-grade acids. The compositions may be employed to remineralize the tooth surfaces of mammals, as well as impart acid resistance thereto.

Claims

1. A chewing gum composition comprising:

(a) a gum base;

(b) at least one non-sugar sweetening agent;

(c) casein phosphopeptide-calcium phosphate in an amount of about 0.5% to about 1.5% by weight of the composition; and

(d) at least one food-grade acid comprising citric acid in an amount of from about 0.5 to about 2.5% by weight of the composition;

wherein said composition provides remineralization of enamel in an amount that is at least about 10% greater than the amount provided by a sweetening agent containing chewing gum composition which comprises an equivalent amount of food-grade acid but which is free of casein phosphopeptide-calcium phosphate; and

wherein said composition provides acid resistance to teeth in an amount that is at least about 4% greater than the amount provided by a sweetening agent containing chewing gum composition which comprises an equivalent amount of food-grade acid but which is free of casein phosphopeptide-calcium phosphate.

2. The chewing gum composition of claim 1, wherein said gum base is present in amounts of about 5% to about 95% by weight of said composition.

3. The chewing gum composition of claim 1, wherein said at least one sweetening agent is present in amounts of about 0.001% to about 95% by weight of said composition.

4. The chewing gum composition of claim 1, wherein said casein phosphopeptide-calcium phosphate is present in amounts of about 0.5% to about 0.769% by weight of said composition.

5. The chewing gum composition of claim 1, wherein said food-grade acid is present in amounts of about 0.5% to about 0.655% by weight of said composition.

6. The chewing gum composition of claim 1, wherein said non-sugar sweetening agent is selected from the group consisting of sugarless bulk sweeteners, high-intensity sweeteners and combinations thereof.

7. The chewing gum composition of claim 1, further comprising at least one flavor.

8. The chewing gum composition of claim 1, wherein said chewing gum composition comprises a chewing gum product selected from the group consisting of slab, pellet, stick, center-fill gum, deposited gum and compressed gum.

9. The chewing gum composition of claim 8, wherein said chewing gum product comprises a chewing gum region and a coating region and said casein phosphopeptide-calcium phosphate is located in a region selected from the group consisting of said chewing gum region, said coating region and combinations thereof.

10. The chewing gum composition of claim 8, wherein said chewing gum product comprises a center-fill gum, said center-fill gum comprising a center-fill region and a gum region at least partially surrounding said center-fill region and said casein phosphopeptide-calcium phosphate is located in a region selected from the group consisting of said gum region, said center-fill region and combinations thereof.

11. The chewing gum composition of claim 1, wherein said casein phosphopeptide-calcium phosphate is encapsulated.

12. The chewing gum composition of claim 1, wherein said casein phosphopeptide-calcium phosphate comprises a mixture of said casein phosphopeptide-calcium phosphate in an encapsulated form and said casein phosphopeptide-calcium phosphate in an unencapsulated form.

13. The chewing gum composition of claim 1, wherein said at least one food-grade acid is encapsulated.

14. The chewing gum composition of claim 1, wherein said at least one food-grade acid comprises a mixture of said at least one food-grade acid in an encapsulated form and said at least one food-grade acid in an unencapsulated form.

15. The chewing gum composition of claim 1, wherein said casein phosphopeptide-calcium phosphate and said at least one food-grade acid are encapsulated together.

16. The chewing gum composition of claim 1, wherein said casein phosphopeptide-calcium phosphate and said at least one food-grade acid are encapsulated separately.

17. The chewing gum composition of claim 1, wherein said composition comprises a chewing gum product comprising about 18 mg of said casein phosphopeptide-calcium phosphate and about 20 mg of said food-grade acid.

18. The chewing gum composition of claim 1, wherein said composition provides about 13% tooth remineralization upon mastication.

19. The chewing gum composition of claim 1, wherein said chewing gum composition comprises a chewing gum product displaying a brand or logo that communicates the presence of said casein phosphopeptide-calcium phosphate and said food-grade acid in amounts sufficient to promote remineralization of tooth surfaces.

20. The chewing gum composition of claim 1, wherein said chewing gum composition comprises a chewing gum product displaying a brand or logo that communicates the presence of said casein phosphopeptide-calcium phosphate and said food-grade acid in amounts sufficient to impart acid resistance to tooth surfaces.

21. A method of imparting acid resistance to the tooth surface of a mammal, comprising the steps of:

(a) applying a chewing gum product into the oral cavity of the mammal, wherein the chewing gum product comprises;

(i) a gum base;

(ii) at least one non-sugar sweetening agent;

(iii) casein phosphopeptide-calcium phosphate in an amount of about 0.5% to about 1.5% by weight of the composition; and

(iv) at least one food-grade acid in an amount of from about 0.5 to about 2.5% by weight of the composition;

wherein said composition provides remineralization of enamel in an amount that is at least about 10% greater than the amount provided by a sweetening agent containing chewing gum composition which comprises an equivalent amount of food-grade acid but which is free of casein phosphopeptide-calcium phosphate; and

wherein said composition provides acid resistance to teeth in an amount that is at least about 4% greater than the amount provided by a sweetening agent containing chewing gum composition which comprises an equivalent amount of food-grade acid but which is free of casein phosphopeptide-calcium phosphate; and

(b) chewing the chewing gum product for a time sufficient to impart acid resistance to the tooth surface of the mammal.

22. The method of claim 21, wherein said casein phosphopeptide-calcium phosphate is present in amounts of about 0.5% to about 0.769% by weight of said product.