Calcium phosphate complex and salts in oral delivery systems

• US 8,133,476 B2
• Filed: 04/05/2007
• Issued: 03/13/2012
• Est. Priority Date: 04/05/2006
• Status: Expired due to Fees

• Current Assignee: Intercontinental Great Brands LLC (Mondelez International, Inc.)
• Original Assignee: Cadbury Adams USA LLC (Mondelez International, Inc.)
• Inventors: Tancredi, Doris, Holme, Samantha, Luo, Shiuh
• Primary Examiner(s): Kishore, Gollamudi
• Assistant Examiner(s): Maewall, Snigdha
• Application Number:
  US11/732,940
• Publication Number:
  US 20070237725A1
• Time in Patent Office: 1,804 Days
• Field of Search: 424/48, 424/50
• US Class Current: 424/48
• CPC Class Codes: A23G 3/362 containing inorganic compounds
• CPC Class Codes: A23G 3/44 containing peptides or proteins containing dairy products A23G3/46
• CPC Class Codes: A23G 4/064 containing inorganic compounds
• CPC Class Codes: A23G 4/14 containing peptides or proteins containing dairy products A23G4/16
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/165 Complexes or chelates
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/1578 Calcium
• CPC Class Codes: A61K 2800/58 Metal complex; Coordination compounds
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The present invention relates to oral delivery systems, such as confectionery and chewing gum compositions, and methods for remineralizing tooth enamel in mammals. In particular, the oral delivery systems include a phosphopeptide or phosphoprotein stabilized calcium phosphate or calcium fluoride phosphate complex and a salt selected from calcium salts, phosphate salts and combinations thereof. The delivery systems promote remineralization of tooth enamel of consumers.

Claims

1. An oral delivery system comprising:

(a) a casein phosphopeptide-calcium phosphate complex; and

(b) a calcium salt and a phosphate salt, wherein each of said salts is a separate and additional component from said complex, and wherein said calcium salt is selected from the group consisting of calcium chloride, calcium lactate, calcium sulfate, calcium carbonates, calcium phosphates, calcium glutareate, calcium malate, calcium citrate, calcium gluconate, calcium glycerophosphate, calcium fumarate, calcium hydroxide, calcium oxide and combinations thereof, and said phosphate salt is selected from the group consisting of neutral, monobasic and dibasic sodium phosphate salts; and

wherein said oral delivery system is a sugar-containing chewing gum or confectionery;

wherein said casein phosphopeptide calcium phosphate complex is present in an amount that is less by weight than that of said salts, and said casein phosphopeptide calcium phosphate complex is present in an amount of from about 0.1% to about 0.5% by weight of said system, said calcium salt is present in an amount of from about 1.5% to about 3.0% by weight of said system, and said phosphate salt is present in an amount of from 1.2% to about 1.8% by weight of said system; and

wherein upon consumption said system provides a level of enamel subsurface remineralization in the tooth of a mammal that is at least about 12.5% greater than the amount of remineralization provided by consumption of a composition which is substantially the same as said system but which is free of said complex and said salts.

2. The oral delivery system of claim 1, wherein said calcium salt is calcium lactate.

3. The oral delivery system of claim 1, wherein said system is a chewing gum.

4. The oral delivery system of claim 1, wherein said system is free of added sodium bicarbonate.