Transdermal delivery system for dried particulate or lyophilized medications
First Claim
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1. A printed patch comprising a non-adhesive liner and a dried pharmaceutical composition comprising a calcitonin present on the non-adhesive liner, wherein the non-adhesive liner is made of a material that is not permeable to the calcitonin.
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Abstract
The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.
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22 Claims
- 1. A printed patch comprising a non-adhesive liner and a dried pharmaceutical composition comprising a calcitonin present on the non-adhesive liner, wherein the non-adhesive liner is made of a material that is not permeable to the calcitonin.
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4. A printed patch comprising a non-adhesive liner and a dried pharmaceutical composition comprising a salmon calcitonin present on the non-adhesive liner and a stabilizer, wherein the salmon calcitonin is salmon calcitonin I as set forth in SEQ ID NO:
- 1, the stabilizer is trehalose, and the non-adhesive liner is made of a material that is not permeable to the calcitonin.
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