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Methods and systems for delivery of fluidic samples to sensor arrays

  • US 8,133,741 B2
  • Filed: 08/22/2006
  • Issued: 03/13/2012
  • Est. Priority Date: 10/26/2005
  • Status: Active Grant
First Claim
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1. A method for simultaneously measuring a plurality of biological or chemical analytes in a fluid, said method comprising the steps of:

  • providing a substrate comprising a plurality of sensor elements, each said sensor element responding to at least one of said plurality of analytes;

    providing at least one light source for directing light onto said sensor elements;

    providing a delivery device having a plurality of reservoirs in communication with said sensor elements, said delivery device comprising a single sample entry port in fluid communication with a plurality of fluidic channels, said channels directly connecting said sample entry port to said reservoirs, wherein the delivery device meters and delivers a controlled volume of said fluid between the sample entry port and the reservoirs, and said delivery device further comprising a cover layer having a plurality of vent holes having hydrophobic walls disposed above said reservoirs, said cover layer further having a hydrophilic bottom surface for providing a hydrophilic roof portion above said reservoirs to facilitate transport of said fluid to said reservoirs;

    delivering a sample fluid to the single sample entry port of the delivery device;

    drawing sample fluid through said fluidic channels with the hydrophilic bottom surface to fill said reservoirs with sample fluid;

    venting air from the delivery device through the vent holes;

    impeding sample fluid from flowing though the vent holes and escaping the reservoirs with the hydrophobic walls of the vent holes to thereby deliver a metered quantity of said sample fluid to each of said sensor elements with said delivery device;

    detecting a response from said sensor elements;

    recording said response into a digital record;

    processing said digital record; and

    utilizing said digital record to determine a concentration of each said analyte in said fluid.

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