Stable composite material comprising supported porous gels

• US 8,133,840 B2
• Filed: 06/06/2005
• Issued: 03/13/2012
• Est. Priority Date: 06/07/2004
• Status: Active Grant

• Current Assignee: Merck Millipore Ltd. (Merck & Co., Inc.)
• Original Assignee: Natrix Separations Inc.
• Inventors: Mika, Alicja M., Wang, Maggie Sanju, Childs, Ronald F.
• Primary Examiner(s): JOHNSON, EDWARD M
• Application Number:
  US11/628,805
• Publication Number:
  US 20080264867A1
• Time in Patent Office: 2,472 Days
• Field of Search: 502/401, 502/402, 502/439, 502/526, 502/515, 502/516
• US Class Current: 502/402
• CPC Class Codes: B01J 20/28033 Membrane, sheet, cloth, pad, lamellar or mat
• CPC Class Codes: B01J 20/28047 Gels
• CPC Class Codes: B01J 20/28078 Pore diameter
• CPC Class Codes: B01J 20/28085 being more than 50 nm, i.e. macropores
• CPC Class Codes: B01J 20/28097 being coated, filled or plugged with specific compounds
• CPC Class Codes: B01J 20/285 based on polymers
• CPC Class Codes: B01J 20/3204 Inorganic carriers, supports or substrates
• CPC Class Codes: B01J 20/321 consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3212 consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/327 Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3272 Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3278 Polymers being grafted on the carrier
• CPC Class Codes: B01J 20/3282 Crosslinked polymers
• CPC Class Codes: C12N 2533/30 Synthetic polymers thermoreactive polymers, e.g. PNIPAm, C12N2539/10
• CPC Class Codes: C12N 5/0068 General culture methods using substrates for specific animal cell type C12N5/06
• CPC Class Codes: Y10S 502/526 Sorbent for fluid storage, other than an alloy for hydrogen storage

Abstract

This invention relates to a stable composite material comprising a support member that has a plurality of pores extending through the support member, and a macroporous crosslinked gel that is located in, and fills, the pores of the support member, in which crosslinked gel is entrapped a stabilizing polymer, which stabilizing polymer is neutral, linear or branched, non-crosslinked, and substantially water-insoluble. The presence of the stabilizing polymer is such that it allows the composite material to largely retain its porosity and morphology after being dried. The invention also relates to a process for preparing the stable composite material described above, and to its use. The stable composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.

Claims

1. A composite material comprising:

a support member that has a plurality of pores extending therethrough, and

a non-self supporting macroporous crosslinked gel that is located in, and fills, the pores of the support member, wherein the macroporous crosslinked gel has macropores of average size between about 10 and about 3000 nm;

wherein, in the macroporous crosslinked gel is entrapped a stabilising polymer selected from the group consisting of a cellulose derivative, a polyester, a polyamide, a polyacrylate, poly(ethylene-co-vinyl alcohol), polyhydroxystyrene (poly(4-vinylphenol), aromatic poly(ether sulfone), a partially charged polymer, and a copolymer of neutral and charged monomers.

2. A composite material according to claim 1, wherein the stabilising polymer has an affinity parameter d₀(H₂O) of from about 12 to about 40.

3. A composite material according to claim 1, wherein the stabilising polymer has an affinity parameter d₀(H₂O) of from about 12 to about 25.

4. A composite material according to claim 1, wherein the stabilising polymer is non-crosslinked.

5. A composite material according to claim 1, wherein the stabilising polymer has a molecular weight of from 5,000 to 500,000.

6. A composite material according to claim 1, wherein the stabilising polymer is present in an amount of from 5% to 50% by weight, based on the combined weight of macroporous gel and stabilising polymer.

7. A composite material according to claim 1, wherein the stabilising polymer is present in an amount of from 10% to 25% by weight, based on the combined weight of macroporous gel and stabilising polymer.

8. A composite material according to claim 1, wherein the stabilising polymer is soluble in a solvent used to prepare the macroporous gel.

9. A composite material according to claim 1, wherein the stabilizing polymer is a cellulose derivative selected from cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, 2-hydroxyethyl cellulose and ethyl cellulose.

10. A composite material according to claim 1, wherein the stabilizing polymer is a polyester selected from poly(ethylene adipate), polyethylene glycol terephthalate, poly(L-lactide), poly(DL-lactide) and poly(dl-lactide-co-glycolide).

11. A composite material according to claim 1, wherein the stabilizing polymer is a polyamide selected from poly(hexamethyleneadipamide) and poly(hexamethylenesebacamide).

12. A composite material according to claim 1, wherein the stabilizing polymer is a polyacrylate selected from poly(2-hydroxyethyl methacrylate) and poly(2-hydroxypropyl methacrylate).

13. A composite material according to claim 1, wherein the stabilizing polymer is poly(ethylene-co-vinyl alcohol) having an ethylene content of 27, 32, 38, or 44 mol-%.

14. A composite material according to claim 1, wherein the stabilizing polymer is a partially charged polymer selected from sulfonated polyetherether ketone (<

86% sulfonation), sulfonated poly(phenylene oxide) (<

70% sulfonation), sulfonated polysulfone (<

70% sulfonation), aminated polysulfone (<

70% amination), aminated poly(phenylene oxide) (<

70% amination) and protonated or alkylated poly(4-vinylpyridine) (<

30% protonation or alkylation).

15. A composite material according to claim 1, wherein the stabilizing polymer is a copolymer of neutral and charged monomers that is a poly(ethylene-co-acrylic acid) copolymer.

16. A composite material according to claim 15, wherein the poly(ethylene-co-acrylic acid) copolymer comprises 5, 10, 15, or 20 wt-% of acrylic acid.

17. A composite material according to claim 1, wherein the stabilising polymer is an ethylene-co-vinyl alcohol copolymer or cellulose acetate.

18. A composite material according to claim 17, wherein the cellulose acetate has a degree of acetylation of from 29 to 61%.