Noninvasive glucose sensing methods and systems
First Claim
1. A method for noninvasive glucose sensing comprising the steps of:
- directing waves including electromagnetic waves, ultrasonic waves or a combination of electromagnetic waves and ultrasonic waves into a target tissue having at least two layers,measuring reflected waves reflected from boundaries between the target tissue and its surroundings and from boundaries between the layers of the target tissue,calculating a value of at least one dimension of the target tissue from the reflected waves, anddetermining a glucose value from the value of the at least one dimension of the target tissue in accordance with a target tissue dimension calibration curve, where the calibration curve correlates the value of the at least one dimension to a corresponding glucose value.
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Abstract
New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.
28 Citations
20 Claims
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1. A method for noninvasive glucose sensing comprising the steps of:
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directing waves including electromagnetic waves, ultrasonic waves or a combination of electromagnetic waves and ultrasonic waves into a target tissue having at least two layers, measuring reflected waves reflected from boundaries between the target tissue and its surroundings and from boundaries between the layers of the target tissue, calculating a value of at least one dimension of the target tissue from the reflected waves, and determining a glucose value from the value of the at least one dimension of the target tissue in accordance with a target tissue dimension calibration curve, where the calibration curve correlates the value of the at least one dimension to a corresponding glucose value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 19, 20)
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11. A method for noninvasive glucose sensing including the steps of:
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directing waves including electromagnetic waves, ultrasonic waves or a combination of electromagnetic waves and ultrasonic waves into a target tissue having at least two layers, measuring times of flight of reflected electromagnetic waves, reflected ultrasonic wave or a combination of reflected electromagnetic waves and reflected ultrasonic waves reflected from boundaries between the target tissue and its surroundings and from boundaries between the layers of the target tissue, and determining a glucose value from the times of flight in accordance with a time of flight versus glucose calibration curve, where the calibration curve correlates the times of flight to a corresponding glucose value. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification