Method and system for managing physiological system

• US 8,137,269 B2
• Filed: 03/15/2007
• Issued: 03/20/2012
• Est. Priority Date: 09/15/2004
• Status: Active Grant

• Current Assignee: K/S HIMPP
• Original Assignee: ON Semiconductor Trading, Ltd (ON Semiconductor Corporation)
• Inventors: Sheikhzadeh-Nadjar, Hamid, Brennan, Robert L., Rice, Michael
• Primary Examiner(s): Yao, Sam
• Assistant Examiner(s): SORIANO, BOBBY GILES
• Application Number:
  US11/724,642
• Publication Number:
  US 20070265508A1
• Time in Patent Office: 1,832 Days
• Field of Search: None
• US Class Current: 600/300
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: G10L 21/0208 Noise filtering
• CPC Class Codes: G10L 25/00 Speech or voice analysis techniques not restricted to a single one of groups G10L15/00 - G10L21/00 muting semiconductor-based amplifiers when some special characteristics of a signal are sensed by a speech detector, e.g. sensing when no signal is present, H03G3/34
• CPC Class Codes: H03H 2021/0041 Subband decomposition
• CPC Class Codes: H03H 21/0012 Digital adaptive filters

Abstract

A method and system for managing physiological systems is provided. The physiological system management (PSM) system includes one or more signal acquisition blocks to collect physiological information. The PSM system includes oversampled filterbanks for transferring one or more input signal related to the physiological information into subband signals, and a subband processing scheme for processing the outputs from the oversampled filterbanks for event detection in one or more physiological systems. The PSM system includes an adaptive controller which decides on the proper control measure and delivers the measure to the one or more physiological systems.

Claims

1. A system for implementing physiological system management (PSM) comprising:

a sensor for acquiring a physiological signal in a time domain from one or more physiological systems;

a Weighted Overlap-Add (WOLA) analysis filterbank for decomposing an input in the time domain, into subband signals;

a subband processor for detecting a predetermined physiological event occurring in the physiological system based on the subband signals, and determining a control for the physiological system based on the detected predetermined physiological event or a combination of the detected predetermined physiological event and the physiological signal, the subband processor extracting a feature of the physiological system;

a WOLA synthesis filterbank for synthesizing one or more of the subband signals output from the subband processor to provide a time domain output signal;

an output combiner for combining the extracted feature with the time domain output signal;

a controller for controlling the physiological system based on the determination; and

a switch for selectively providing, to the input of the WOLA analysis filterbank, the output of the output combiner or the physiological signal in the time domain.

2. The system according to claim 1, further comprising:

a time-domain processor for processing the physiological signal to detect a predetermined time-domain physiological event, wherein the detected predetermined time-domain physiological event and the detected predetermined physiological event are used to determine the control.

3. The system according to claim 1, wherein the subband processor extracts a feature of the physiological signal from the subband signals, the processor comprising an event detection block for detecting the predetermined physiological event based on the extracted feature.

4. The system according to claim 3, further comprising:

means having a memory, for compressing and transmitting the physiological signals, the output signals from the system, the detected feature and the predetermined physiological event, and a telemetry for monitoring the system performance.

5. The system according to claim 1, further comprising a receiver for receiving data and command from outside of the system.

6. The system according to claim 3, wherein the subband processor implements a signal enhancement for removing noise or interference and enhancing the feature.

7. The system according to claim 3, wherein the PSM is cardiac rhythm management (CRM) where the feature is extracted by calculating absolute values or squared absolute values of each subband signal, and combining calculated values for subbands in each designated subband group, each group including one or more subbands, to obtain subband energy.

8. The system according to claim 7, wherein the subband energies are further processed for detecting one or more peaks by tracking average and maximum values of the corresponding subband energy through time-averaging.

9. The system according to claim 8, wherein the detected peaks are represented in a binary format containing “

0”

, “

1”

or a combination thereof for each subband group, the “

0”

representing one of peak and no-peak, and the “

1”

representing the other, the binary decisions being combined by a combiner.

10. The system according to claim 9, wherein the combiner includes logical AND, logical OR operations, or combinations thereof.

11. The system according to claim 7, further comprising means for processing the subband energies and detecting one or more peaks by periodicity tracking using autocorrelation of one or more subband groups, an estimation of the autocorrelation, cross-correlation of multiple subband groups, an estimation of the cross-correlation, or combinations thereof.

12. The system according to claim 6, where the physiological system includes an autonomous nervous system where the acquisition module senses heart rate variability or other physiological information in the an autonomous nervous system.

13. The system according to claim 6, where the PSM includes an automatic drug delivery (ADD).

14. The system according to claim 6, where the PSM includes a cardiac rhythm management (CDM) and ADD applications.

15. The system according to claim 6, where the physiological system includes a brain and nervous system for controlling one or more neurological diseases.

16. The system according to claim 15, wherein the neurological disease includes epilepsy, seizure, or a combination thereof.

17. The system according to claim 6, where the PSM is applied to control a neuromuscular system.

18. The system according to claim 6, where the PSM is applied to a heart system, a brain system, an autonomous system, or combinations thereof.

19. The system according to claim 1, wherein the controller operates in a closed-loop, the controller monitoring the one or more physiological systems and adapting the control measure accordingly.

27. The system according to claim 1, wherein the subband signals are complex-valued signals.

20. A method of implementing physiological system management (PSM), comprising:

acquiring, by a sensor, a physiological signal in a time domain from one or more physiological systems;

decomposing, by a Weighted Overlap-Add (WOLA) analysis filterbank, an input of the WOLA analysis filterbank in the time domain, into subband signals;

in a subband processor, extracting a feature of the physiological system, detecting a predetermined physiological event occurring in the physiological system based on the subband signals, and determining a control for the physiological system based on the detected predetermined physiological event or a combination of the detected predetermined physiological event and the physiological signal;

synthesizing, by a WOLA synthesis filterbank, one or more of the subband signals output from the subband processor to provide a time domain output signal;

combining, by an output combiner, the extracted feature with the time domain output signal;

controlling, by a controller, the physiological system based on the determination; and

selectively providing, to the input of the WOLA analysis filterbank, the output of the output combiner or the physiological signal in the time domain.

21. A method according to claim 20, further comprising the step of:

monitoring the physiological information and repeating the decomposing, detecting, decision-making and applying steps.

22. A method according to claim 21, wherein the decision-making step includes the step of:

adapting a control strategy based on evaluation of the applied control measure.

23. A method according to claim 20, wherein the step of extracting comprises:

extracting a feature of the physiological signal from the subband signals, the event detection step detecting the predetermined physiological event based on the extracted feature.

24. A method according to claim 23, further comprising:

removing noise or interference and enhancing the feature in the subband domain.

25. A method according to claim 20, further comprising:

receiving one or more data to control the collecting step, the decomposing step, the detecting step, the determining step, the controlling step, or combinations thereof.

26. A computer readable medium having recorded thereof statements and instructions for executing by a computer to carry out the method of claim 20.

28. A method according to claim 20, wherein the subband signals are complex-valued signals.