Methods to deliver high intensity focused ultrasound to target regions proximate blood vessels

• US 8,137,274 B2
• Filed: 02/11/2011
• Issued: 03/20/2012
• Est. Priority Date: 10/25/1999
• Status: Active Grant

• Current Assignee: Otsuka Medical Devices Co., Ltd. (Otsuka Holdings Company Limited)
• Original Assignee: Kona Medical, Inc.
• Inventors: Weng, Lee, Zhang, Jimin, Perozek, David M
• Primary Examiner(s): KISH, JAMES M
• Application Number:
  US13/025,959
• Publication Number:
  US 20110178403A1
• Time in Patent Office: 403 Days
• Field of Search: 600/407, 600/437, 600/439, 600/443, 600/444, 600/448, 600/454, 601/2
• US Class Current: 600/437
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 2017/00504 Tissue welding
• CPC Class Codes: A61B 2017/00641 for closing fistulae, e.g. anorectal fistulae
• CPC Class Codes: A61B 2017/00907 for light
• CPC Class Codes: A61B 2090/062 penetration depth
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 2090/3904 specially adapted for marking specified tissue
• CPC Class Codes: A61B 2090/3937 Visible markers
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 8/4422 related to hygiene or sterilisation
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G10K 11/32 characterised by the shape of the source
• CPC Class Codes: G10K 11/346 using phase variation

Abstract

Methods for applying heat to a region proximate a blood vessel are disclosed. In one embodiment, a method can include generating an imaging ultrasound beam adapted to image a blood vessel target and receiving a reflection of the imaging ultrasound beam. The method can also include producing an output signal in response to the reflection of the imaging ultrasonic beam and processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel. Therapeutic energy can be applied to the treatment zone. In some embodiments, the therapeutic ultrasound energy beam can be moved to over-scan the treatment zone. Other methods are also disclosed.

Claims

1. A method of non-invasively applying heat to a region proximate to a blood vessel target, the method comprising:

generating an imaging ultrasonic beam adapted to image the blood vessel target, the blood vessel target having a puncture site;

receiving a reflection of the imaging ultrasonic beam and in response producing a corresponding output signal;

processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel target;

detecting the presence of a nerve structure adjacent to the blood vessel target by applying an ultrasonic pulse to the treatment zone;

applying a therapeutic ultrasound energy beam to the treatment zone, wherein the ultrasound energy beam is a high intensity focused ultrasound energy beam; and

moving the therapeutic ultrasound energy beam to over-scan the treatment zone with therapeutic ultrasonic energy,

wherein the imaging ultrasonic beam, the ultrasonic pulse, and the therapeutic ultrasound energy beam are transcutaneously applied.

2. The method of claim 1, wherein the therapeutic ultrasound energy beam is movable in a plurality of directions at any given time.

3. The method of claim 1, wherein the therapeutic ultrasound energy beam is applied by an ultrasonic transducer applicator.

4. The method of claim 3, wherein the ultrasonic transducer applicator comprises an array of transducers.

5. The method of claim 4, wherein the array of transducers is configured to emit the imaging ultrasonic beam.

6. The method of claim 1, further comprising the step of interrupting the application of the therapeutic ultrasound beam to generate a second imaging ultrasonic beam to confirm that the therapeutic ultrasound beam is being directed to the treatment zone.

7. The method of claim 1, wherein the intensity of the ultrasonic pulse is less than about 1,000 Watts per square centimeter.

15. The method of claim 1, wherein the presence of the nerve structure is determined based on the pain of a patient in response to the ultrasonic pulse.

16. The method of claim 1, wherein a direction of the therapeutic ultrasound energy beam is oriented with respect to a direction of flow in the blood vessel.

8. A method of non-invasively applying heat to a region proximate to a blood vessel target, the method comprising:

directing an imaging ultrasonic beam proximate the blood vessel target, the blood vessel target having a puncture site;

receiving a reflection of the imaging ultrasonic beam;

processing the reflection of the imaging ultrasonic beam to identify a location of a treatment zone proximate an outer wall of the blood vessel target;

detecting the presence of a nerve structure adjacent to the blood vessel target by applying an ultrasonic pulse to the treatment zone;

applying a high intensity focused ultrasound beam to the treatment zone; and

moving the high intensity focused ultrasound beam to over-scan the treatment zone with therapeutic ultrasonic energy,

wherein the imaging ultrasonic beam, the ultrasonic pulse, and the therapeutic ultrasound energy beam are transcutaneously applied.

9. The method of claim 8, wherein the high intensity focused ultrasound beam is movable in a plurality of directions at any given time.

10. The method of claim 8, wherein the high intensity focused ultrasound beam is applied by an ultrasonic transducer applicator.

11. The method of claim 10, wherein the ultrasonic transducer applicator comprises an array of transducers.

12. The method of claim 11, wherein the array of transducers is configured to emit the imaging ultrasonic beam.

13. The method of claim 8, further comprising the step of interrupting the application of the high intensity focused ultrasound beam to generate a second imaging ultrasonic beam to confirm that the high intensity focused ultrasound beam is being directed to the treatment zone.

14. The method of claim 8, wherein the intensity of the ultrasonic pulse is less than about 1,000 Watts per square centimeter.

17. A method of applying heat to a region proximate to a blood vessel, the method comprising:

generating an imaging ultrasonic beam adapted to image a blood vessel target;

receiving a reflection of the imaging ultrasonic beam and in response producing a corresponding output signal;

processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel target;

detecting the presence of a nerve structure by applying an ultrasonic pulse to the treatment zone, the ultrasonic pulse having an intensity that is less than 1,000 Watts per square centimeter;

applying a therapeutic ultrasound energy beam to the treatment zone, wherein the ultrasound energy beam is a high intensity focused ultrasound energy beam; and

moving the therapeutic ultrasound energy beam to over-scan the treatment zone with therapeutic ultrasonic energy,

wherein the imaging ultrasonic beam, the ultrasonic pulse, and the therapeutic ultrasound energy beam are transcutaneously applied.

18. The method of claim 17, wherein the presence of the nerve structure is determined based on the pain of a patient in response to the ultrasonic pulse.

19. The method of claim 17, wherein a direction of the therapeutic ultrasound energy beam is oriented with respect to a direction of flow in the blood vessel.

20. The method of claim 17, wherein the therapeutic ultrasound energy beam is movable in a plurality of directions at any given time.

21. The method of claim 17, wherein the therapeutic ultrasound energy beam is applied by an ultrasonic transducer applicator.

22. The method of claim 21, wherein the ultrasonic transducer applicator comprises an array of transducers.

23. The method of claim 22, wherein the array of transducers is configured to emit the imaging ultrasonic beam.

24. The method of claim 17, further comprising the step of interrupting the application of the therapeutic ultrasound beam to generate a second imaging ultrasonic beam to confirm that the therapeutic ultrasound beam is being directed to the treatment zone.

25. A method of treating a patient, the method comprising:

directing an imaging ultrasonic beam proximate a blood vessel;

receiving a reflection of the imaging ultrasonic beam;

processing the reflection of the imaging ultrasonic beam to identify a location of a treatment zone proximate an outer wall of the blood vessel;

detecting the presence of a nerve structure by applying an ultrasonic pulse to the treatment zone, the ultrasonic pulse having an intensity that is less than 1,000 Watts per square centimeter;

applying a high intensity focused ultrasound beam to the treatment zone; and

moving the high intensity focused ultrasound beam to over-scan the treatment zone with therapeutic ultrasonic energy,

wherein the imaging ultrasonic beam, the ultrasonic pulse, and the therapeutic ultrasound energy beam are transcutaneously applied.

26. The method of claim 25, wherein the high intensity focused ultrasound beam is movable in a plurality of directions at any given time.

27. The method of claim 25, wherein the high intensity focused ultrasound beam is applied by an ultrasonic transducer applicator.

28. The method of claim 27, wherein the ultrasonic transducer applicator comprises an array of transducers.

29. The method of claim 28, wherein the array of transducers is configured to emit the imaging ultrasonic beam.

30. The method of claim 25, further comprising the step of interrupting the application of the high intensity focused ultrasound beam to generate a second imaging ultrasonic beam to confirm that the high intensity focused ultrasound beam is being directed to the treatment zone.