Medical devices

• US 8,137,397 B2
• Filed: 02/26/2004
• Issued: 03/20/2012
• Est. Priority Date: 02/26/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Colen, Fredericus A., Knapp, David
• Primary Examiner(s): Stewart, Alvin J
• Application Number:
  US10/787,618
• Publication Number:
  US 20050192657A1
• Time in Patent Office: 2,945 Days
• Field of Search: 623/1.4, 623/1.11, 623/1.13, 623/1.23, 623 138- 154, 623/1.15
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2310/0097 Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics

Abstract

Medical devices, particularly stents, suitable for drug delivery and including a sugar, sugar derivative, inorganic ionic salt, polysaccharide, amino acid, amino acid derivative, polypeptide, surfactant, or combination thereof, are disclosed.

Claims

1. A medical stent, comprising:

a generally tubular body;

a reservoir containing a first therapeutic agent; and

a body-fluid dissolvable protective layer disposed over the generally tubular body, the layer consisting essentially of an inorganic ionic salt selected from the group consisting of sodium chloride, potassium chloride, and sodium carbonate,

wherein

the layer covers the reservoir, and

the reservoir is formed of a bioerodible material.

2. The medical stent of claim 1 wherein the layer includes a second therapeutic agent.

3. The medical stent of claim 2 wherein the second therapeutic agent is different from the first therapeutic agent.

4. The medical stent of claim 1 wherein the reservoir is a layer of the first therapeutic agent.

5. The medical stent of claim 1 wherein the reservoir defines pores and the first therapeutic agent is disposed within the pores.

6. The medical stent of claim 1 wherein the reservoir comprises metal integral with the stent body.

7. The medical stent of claim 1 wherein the first therapeutic agent is selected from an group consisting of an antithrombogenic, antioxidant, anti-inflammatory, antiproliferative, or antibiotic.

8. The medical stent of claim 1 wherein the stent is a self-expanding stent.

9. The medical stent of claim 1 wherein the stent is a balloon-expandable stent.

10. The medical stent of claim 1 wherein the stent is a vascular stent.

11. The medical stent of claim 1, wherein the layer consists of an inorganic ionic salt selected from the group consisting of sodium chloride, potassium chloride, and sodium carbonate.

12. The implantable medical device of claim 11, wherein the bioerodible material comprises a bioerodible polymer.

13. The medical stent of claim 1 wherein the bioerodible material comprises a bioerodible polymer.

14. An implantable medical device, comprising:

an implantable body;

a reservoir containing a therapeutic agent; and

a body-fluid dissolvable protective layer disposed over the implantable body, the layer consisting essentially of an inorganic ionic salt selected from the group consisting of sodium chloride, potassium chloride, and sodium carbonate,

wherein

the layer covers the reservoir, and

the reservoir is formed of a bioerodible material.

15. The implantable medical device of claim 14, wherein the implantable medical device is a balloon angioplasty catheter.

16. An implantable medical device, of claim 14, wherein the bioerodible material comprises a bioerodible polymer.