Synthesis of cationic siloxane prepolymers

• US 8,138,288 B2
• Filed: 03/03/2011
• Issued: 03/20/2012
• Est. Priority Date: 01/26/2007
• Status: Expired due to Fees

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Stanbro, Jason K., Nunez, Ivan M., Kunzler, Jay F., Schorzman, Derek A.
• Primary Examiner(s): Choi, Ling
• Assistant Examiner(s): WANG, CHUN CHENG
• Application Number:
  US13/039,912
• Publication Number:
  US 20110146206A1
• Time in Patent Office: 383 Days
• Field of Search: 526/279, 534/25, 523/107, 528/120
• US Class Current: 526/279
• CPC Class Codes: C08G 77/388 containing nitrogen
• CPC Class Codes: C08L 83/08 containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.

Claims

1. A device comprising a polymerization product of a monomer mixture useful for making polymerized biomaterials comprising at least one monomer having the following formula:

2. The device of claim 1 wherein the device is a contact lens.

3. The device of claim 2 wherein the contact lens is a rigid gas permeable contact lens.

4. The device of claim 2 wherein the contact lens is a soft contact lens.

5. The device of claim 2 wherein the contact lens is a hydrogel contact lens.

6. The device of claim 1 wherein the device is an intraocular lens.

7. The device of claim 6 wherein the intraocular lens is a phakic intraocular lens.

8. The device of claim 6 wherein the intraocular lens is an aphakic intraocular lens.

9. The device of claim 1 wherein the device is a corneal implant.

10. The device of claim 1 wherein the device is selected from the group consisting of heart valves, films, surgical devices, vessel substitutes, intrauterine devices, membranes, diaphragms, surgical implants, blood vessels, artificial ureters, artificial breast tissue, membranes for kidney dialysis machines, membranes for heart/lung machines, catheters, mouth guards, denture liners and ophthalmic devices.

11. A method of making a device comprising:

providing a monomer mixture comprising a monomer having the following formula;

12. The method of claim 11 wherein the step of extracting is performed with non-flammable solvents.

13. The method of claim 11 wherein the step of extracting is performed with water.

14. The method of claim 11 further comprising the step of packaging and sterilizing the polymerized device.