Convenient synthesis of 1→3 C - branched dendrons
First Claim
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1. A method of preparing a 1→
- 3 C-branched dendrimer, the method comprising the steps of;
reacting an amine with at least acryloyl chloride to form a N-substituted amide;
reacting the N-substituted amide with at least nitromethane to form a second amide;
reacting the N-substituted amide and the second amide at a predetermined ratio to form a predendron;
hydrogenating the predendron in the presence of a catalyst to form an amine dendron; and
reacting the amine dendron with at least an amount of triphosgene to form an isocyanate dendron.
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Abstract
In accordance with the present invention, there is provided a method of preparing higher generation 1→3 C-branched polyamide dendrons. The combination of commercially available acryloyl chloride with 1→3 C-branched amines, e.g., di-tert-butyl 4-[2-(tert-butoxycarbonyl)ethyl]-4-aminoheptanedioate, resulted in generally high yields of acryl amides, which upon treatment with other reagents, generated the desired higher generation dendrons. These second and third generation dendrons were fully characterized and compared to the samples prepared from a convergent synthesis.
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7 Claims
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1. A method of preparing a 1→
- 3 C-branched dendrimer, the method comprising the steps of;
reacting an amine with at least acryloyl chloride to form a N-substituted amide; reacting the N-substituted amide with at least nitromethane to form a second amide; reacting the N-substituted amide and the second amide at a predetermined ratio to form a predendron; hydrogenating the predendron in the presence of a catalyst to form an amine dendron; and reacting the amine dendron with at least an amount of triphosgene to form an isocyanate dendron. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- 3 C-branched dendrimer, the method comprising the steps of;
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