Membrane active heteropolymers
First Claim
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1. A membrane active amine-containing random copolymer, wherein said polymer comprises:
- plurality of first monomers each containing a pendant primary amine group, a plurality of second monomers each containing a pendant linear alkyl group having two to four carbon atoms, and a plurality of third monomers each containing a pendant linear alkyl group having eight or more carbon atoms wherein said random copolymer is capable of lysing red blood cells.
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Abstract
The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
34 Citations
16 Claims
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1. A membrane active amine-containing random copolymer, wherein said polymer comprises:
- plurality of first monomers each containing a pendant primary amine group, a plurality of second monomers each containing a pendant linear alkyl group having two to four carbon atoms, and a plurality of third monomers each containing a pendant linear alkyl group having eight or more carbon atoms wherein said random copolymer is capable of lysing red blood cells.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
Specification