Heart monitoring device and a system to detect vibrations concerning the status of the heart

• US 8,140,158 B2
• Filed: 06/16/2005
• Issued: 03/20/2012
• Est. Priority Date: 06/16/2005
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Inventors: Nilsson, Kenth
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US11/916,461
• Publication Number:
  US 20080269820A1
• Time in Patent Office: 2,469 Days
• Field of Search: 607 17- 18
• US Class Current: 607/18
• CPC Class Codes: A61B 5/103 Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes A61B5/08 takes precedence; measuring aids for tailors A41H1/00; measuring instruments specially adapted for dentistry A61C19/04
• CPC Class Codes: A61B 5/4519 Muscles A61B5/389, A61B5/224 take precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36528 the parameter being measured by means of ultrasound
• CPC Class Codes: A61N 2001/0585 Coronary sinus electrodes

Abstract

An implantable heart monitoring system has a control circuit that operates an implanted vibrator to emit a vibration signal that interacts with tissue in vivo. A vibration sensor detects vibrations after interaction with the tissue, and supplies a detection signal to the control circuit. The control circuit analyzes the vibrations in the detected signal relative to the vibration signal, and derives information concerning at least one mechanical property of the heart therefrom, such as stiffness and/or thickness of at least a part of the heart.

Claims

1. An implantable heart monitoring system comprising:

a housing configured for implantation in a subject;

a vibrator configured for implantation in the subject and operable to emit a vibration signal from a first in vivo site into cardiac tissue exhibiting a tissue transfer function representing physical properties of the cardiac tissue in the subject;

a vibration sensor configured for implantation at a second in vivo site in the subject, said vibration sensor configured to detect said vibration signal after said vibration signal has propagated through said tissue between said first in vivo site and said second in vivo site and is further configured to emit a detection signal that represents the detected vibrations; and

a control circuit in said housing in communication with said vibrator and said vibration sensor, said control circuit being configured to execute a procedure comprising actuating said vibrator to emit said vibration signal and receiving said detection signal from said vibration sensor, and to derive based on the detected vibrations in relation to the vibration signal said tissue transfer function, and to derive from said tissue transfer function, information describing at least one medical property of the heart of the subject, selected from the group consisting of stiffness of a heart portion of the heart and a thickness of a portion of the heart.

2. A system as claimed in claim 1 wherein said vibrator is located outside of said housing and is separately implantable in the subject.

3. A system as claimed in claim 2 wherein said vibration sensor is built into said housing.

4. A system as claimed in claim 1 wherein said vibrator is built into said housing.

5. A system as claimed in claim 1 wherein said vibration sensor is located outside of said housing and is separately implantable in the subject.

6. A system as claimed in claim 1 wherein said control circuit, in said procedure, derives a mechanical transfer function representing mechanical properties of in vivo tissue between said vibrator and said vibration sensor, as said information.

7. A system as claimed in claim 1 comprising a memory in communication with said control circuit, and wherein said control circuit is operable in time cycles corresponding to heart cycles of the heart, and wherein said control circuit executes said procedure a plurality of times, with a plurality of time cycles between each execution, and stores a result from each execution of the procedure in the memory, as respective stored results, and derives said information based on a change between successive stored results.

8. A system as claimed in claim 7 wherein said control circuit executes said procedure in a same portion of each time cycle in which the procedure is executed.

9. A system as claimed in claim 1 wherein said control circuit operates said vibrator to emit respective vibration signals having at least two different frequencies, and wherein said vibration sensor discriminates between said two different frequencies in said detection signal.

10. A system as claimed in claim 1 wherein said control circuit derives said information from a characteristic of the detected vibrations in said detection signal selected from the group consisting of amplitude, phase angle, energy content and morphology.

11. A system as claimed in claim 1 wherein said control circuit operates said vibrator to emit said vibration signal as a short burst, and derives said information from a determination of a time beginning from emission of the vibration signal to detection of said detection signal.

12. A system as claimed in claim 1 wherein said vibration sensor is a first vibration sensor implanted separate from said housing, and wherein said system comprises a second vibration sensor built into said housing and connected to said control circuit, and wherein said second vibration sensor emits a further detection signal representing vibration of the housing, and wherein said control circuit derives said information based on said detection signal from said first vibration sensor and said further detection signal from said second vibration sensor.

13. A system as claimed in claim 12 wherein said control circuit derives said information by comparing said detection signal and said further detection signal.

14. A system as claimed in claim 1 comprising a posture detector in said housing that detects when the subject is likely to be at rest, and wherein said control circuit executes said procedure only when said posture detector indicates that the subject is likely to be at rest.

15. A system as claimed in claim 1 wherein said vibrator is operable by said control circuit in an alarm mode wherein said vibrator emits an alarm mode vibration signal having an intensity and duration so as to be perceivable by the subject to alert the subject.

16. A system as claimed in claim 1 comprising a pulse generator in said housing that emits stimulation pulses, and at least one electrode in communication with said pulse generator that delivers said stimulation pulses to cardiac tissue, and wherein said control circuit controls operation of said pulse generator dependent on said information.

17. A method for monitoring cardiac tissue comprising the steps of:

implanting a vibrator in a subject at a first in vivo site;

implanting a vibration sensor in the subject at a second in vivo site, separated from said first in vivo site by cardiac tissue exhibiting a tissue transfer function that represents mechanical properties of said tissue;

emitting vibrations in vivo from said vibrator that interact with said cardiac tissue and detecting vibrations with said vibration sensor resulting from the interaction of the emitted vibrations with cardiac tissue; and

automatically electronically analyzing the detected vibrations to derive said tissue transfer function, and to derive from said transfer function, information describing a mechanical property of the heart of the subject, selected from the group consisting of stiffness of a portion of the heart and thickness of a portion of the heart.

18. A method as claimed in claim 17 comprising emitting said vibration signal and detecting the vibrations after interaction with cardiac tissue in a procedure, and executing said procedure multiple times, separated by a plurality of heart cycles there between, and automatically electronically deriving said information based on change of said at least one mechanical property between successive executions of said procedure.

19. A method as claimed in claim 17 comprising deriving said information from a characteristic of the detected vibrations selected from the group consisting of amplitude, phase angle, energy content, and morphology.

20. A method as claimed in claim 17 comprising emitting said vibrations as a short burst, and deriving said information based on a time beginning from emission of the vibration signal to detection of the detected vibrations.

21. A method as claimed in claim 17 comprising emitting said vibration signal and detecting the vibrations after interaction with cardiac tissue only at a time when the subject is likely to be at rest.

22. A method as claimed in claim 17 comprising analyzing said information to assess a degree of congestive heart failure of the subject.

23. A method as claimed in claim 17 comprising delivering electrical stimulation pulses to the heart of the subject and controlling delivery of the stimulation pulses dependent on said information.