Modified human growth hormone
First Claim
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1. A method of increasing percent body weight by administering a human growth hormone (hGH) composition, wherein said hGH is linked to at least one water-soluble polymer by an oxime bond and wherein the hGH comprises a non-naturally encoded amino acid wherein the non-naturally encoded amino acid has the structure:
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Abstract
Modified growth hormone polypeptide and uses thereof are provided.
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4 Claims
- 1. A method of increasing percent body weight by administering a human growth hormone (hGH) composition, wherein said hGH is linked to at least one water-soluble polymer by an oxime bond and wherein the hGH comprises a non-naturally encoded amino acid wherein the non-naturally encoded amino acid has the structure:
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4. A method of increasing percent body weight by administering a human growth hormone (hGH) composition twice in a fourteen day interval, wherein the amount of hGH composition administered over a 14-day interval has a ≧
- 50% dose-sparing effect when compared to the amount of somatotropin administered over a 14-day interval required to affect an equal or better increase in percent body weight, and wherein said hGH is linked to at least one water-soluble polymer by an oxime bond and wherein the oxime bond is formed between a non-naturally encoded amino acid and a water-soluble polymer.
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