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Tyrosine kinase receptor antagonists and methods of treatment for breast cancer

  • US 8,143,226 B2
  • Filed: 10/25/2006
  • Issued: 03/27/2012
  • Est. Priority Date: 10/28/2005
  • Status: Active Grant
First Claim
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1. A method of treating a human breast cancer patient, wherein breast cancer cells in the cancer patient express Her2/neu receptor, comprising the steps of:

  • administering to the patient a therapeutically effective amount of a formulation comprising;

    (1) a pharmaceutically acceptable carrier;

    (2) nordihydroguaiaretic acid (NDGA) or pharmaceutically acceptable salts thereof; and

    (3) doxorubicin, wherein the NDGA and doxorubicin act synergistically to inhibit growth of the breast cancer cells, and wherein doxorubicin and NDGA are administered in amounts below a therapeutically effective amount of either doxorubicin or NDGA when doxorubicin or NDGA are administered alone.

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