Methods and apparatus for renal neuromodulation
First Claim
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1. A method for renal neuromodulation, the method comprising:
- extravascularly positioning an electrode proximate to a renal nerve that innervates a kidney of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, and chronic renal failure; and
delivering an electric field via the electrode that modulates the renal nerve in a manner that significantly improves a measurable physiological parameter corresponding to the diagnosed disease, wherein the electric field reduces neural communication along the renal nerve,wherein the kidney continues to secrete renin in the patient after delivering the electric field.
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Abstract
Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.
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Citations
41 Claims
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1. A method for renal neuromodulation, the method comprising:
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extravascularly positioning an electrode proximate to a renal nerve that innervates a kidney of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, and chronic renal failure; and delivering an electric field via the electrode that modulates the renal nerve in a manner that significantly improves a measurable physiological parameter corresponding to the diagnosed disease, wherein the electric field reduces neural communication along the renal nerve, wherein the kidney continues to secrete renin in the patient after delivering the electric field. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method for renal neuromodulation, the method comprising:
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percutaneously advancing an electrode under Computed Tomography-guidance until the electrode is extravascularly located proximate to post-ganglionic neural fibers that innervate a kidney of a human patient; and Delivering an electric field via the electrode that modulates the neural fibers in a manner that significantly improves a measurable physiological parameter corresponding to at least one of heart failure hypertension, acute myocardial infarction, impaired renal function, and chronic renal failure, wherein the kidney continues to secrete renin in the patient after delivering the electric field.
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41. A method for treatment of a human patient via renal denervation, the method comprising:
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percutaneously positioning a renal denervation probe having an electrode proximate to a renal nerve that innervates a kidney of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, and chronic renal failure; and delivering an electric field via the electrode that modulates the renal nerve in a manner that significantly improves a measurable physiological parameter corresponding to the diagnosed disease, wherein the electric field reduces neural communication along the renal nerve, wherein the kidney continues to secrete renin in the patient after delivering the electric field.
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Specification