System and method for detection of pulmonary embolism
First Claim
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1. A method, comprising:
- ambulatorily sensing pulmonary artery pressure from within a patient;
producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure;
ambulatorily providing power within the patient to facilitate the sensing of the pulmonary artery pressure and the producing of the pulmonary artery pressure measurement;
detecting acute pulmonary embolism based on a change in the pulmonary artery pressure measurement; and
discriminating, using a processor, between acute pulmonary embolism and primary pulmonary hypertension based on a rate of change of the pulmonary artery pressure measurement.
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Abstract
Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.
68 Citations
31 Claims
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1. A method, comprising:
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ambulatorily sensing pulmonary artery pressure from within a patient; producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure; ambulatorily providing power within the patient to facilitate the sensing of the pulmonary artery pressure and the producing of the pulmonary artery pressure measurement; detecting acute pulmonary embolism based on a change in the pulmonary artery pressure measurement; and discriminating, using a processor, between acute pulmonary embolism and primary pulmonary hypertension based on a rate of change of the pulmonary artery pressure measurement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A system, comprising:
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an implantable pressure sensor configured to ambulatorily sense pulmonary artery pressure from within a patient, the pressure sensor comprising; a support structure comprising a stabilizing arrangement configured to stabilize the pressure sensor within a pulmonary artery of the patient; a pressure transducer; a communications device coupled to the pressure transducer, the communications device configured to effect wireless transmission of a pulmonary artery pressure waveform out of the patient'"'"'s heart, the pressure transducer and the communications device supported by the support structure; and a battery configured to supply power for the pressure transducer and the communications device; and a processor communicatively coupled to the communications device of the pressure sensor, the processor executing programmed instructions for detecting acute pulmonary embolism based on a change in a pulmonary artery pressure measurement derived from the pulmonary artery pressure waveform, the processor executing programmed instructions for discriminating between acute pulmonary embolism and primary pulmonary hypertension based on a rate of change of the pulmonary artery pressure measurement. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method, comprising:
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ambulatorily sensing pulmonary artery pressure from within a patient; producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure; ambulatorily providing power within the patient to facilitate the sensing of the pulmonary artery pressure and the producing of the pulmonary artery pressure measurement; detecting acute pulmonary embolism based on a change in the pulmonary artery pressure measurement; and discriminating, using a processor, between chronic pulmonary embolism and primary pulmonary hypertension based on one or more of a fractional pulse pulmonary artery pressure derived from a waveform indicative of the sensed pulmonary artery pressure, a coefficient of variation of the pulmonary artery pressure derived from the pulmonary artery pressure waveform, and a fractional time to half the area under the pulmonary artery pressure waveform.
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31. A system, comprising:
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an implantable pressure sensor configured to ambulatorily sense pulmonary artery pressure from within a patient, the pressure sensor comprising; a support structure comprising a stabilizing arrangement configured to stabilize the pressure sensor within a pulmonary artery of the patient; a pressure transducer; a communications device coupled to the pressure transducer, the communications device configured to effect wireless transmission of a pulmonary artery pressure waveform out of the patient'"'"'s heart, the pressure transducer and the communications device supported by the support structure; and a battery configured to supply power for the pressure transducer and the communications device; and a processor communicatively coupled to the communications device of the pressure sensor, the processor executing programmed instructions for detecting acute pulmonary embolism based on a change in a pulmonary artery pressure measurement derived from the pulmonary artery pressure waveform, the processor executing programmed instructions for discriminating between chronic pulmonary embolism and primary pulmonary hypertension based on one or more of a fractional pulse pulmonary artery pressure derived from the pulmonary artery pressure waveform, a coefficient of variation of the pulmonary artery pressure derived from the pulmonary artery pressure waveform, and a fractional time to half the area under the pulmonary artery pressure waveform.
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Specification