Implantable systemic blood pressure measurement systems and methods
First Claim
1. A method for monitoring a patient'"'"'s arterial blood pressure with an arterial blood pressure monitor, the method comprising:
- (a) using implanted electrodes to obtain a first signal indicative of electrical activity of the patient'"'"'s heart;
(b) using an implanted sensor to obtain a second signal indicative of mechanical activity of the patient'"'"'s heart;
(c) transmitting said first and said second signal to said arterial blood pressure monitor, said arterial blood pressure monitor comprising a microcontroller;
(d) detecting with said microcontroller a ventricular depolarization and a ventricular repolarization in a portion of the first signal corresponding to a cardiac cycle;
(e) detecting with said microcontroller a maximum peak amplitude in a portion of the second signal corresponding to the same cardiac cycle;
(f) determining with said microcontroller a time t1 from the detected ventricular depolarization to the detected maximum peak amplitude in the second signal;
(g) determining with said microcontroller a time t2 from the detected ventricular repolarization to the detected maximum peak amplitude in the second signal;
(h) determining with said microcontroller a peak pulse arrival time (PPAT) based on times t1 and t2; and
(i) determining with said microcontroller a value indicative of systolic pressure (SP) based on the PPAT.
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Accused Products
Abstract
Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient'"'"'s heart, and a second signal indicative of mechanical activity of the patient'"'"'s heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
47 Citations
26 Claims
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1. A method for monitoring a patient'"'"'s arterial blood pressure with an arterial blood pressure monitor, the method comprising:
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(a) using implanted electrodes to obtain a first signal indicative of electrical activity of the patient'"'"'s heart; (b) using an implanted sensor to obtain a second signal indicative of mechanical activity of the patient'"'"'s heart; (c) transmitting said first and said second signal to said arterial blood pressure monitor, said arterial blood pressure monitor comprising a microcontroller; (d) detecting with said microcontroller a ventricular depolarization and a ventricular repolarization in a portion of the first signal corresponding to a cardiac cycle; (e) detecting with said microcontroller a maximum peak amplitude in a portion of the second signal corresponding to the same cardiac cycle; (f) determining with said microcontroller a time t1 from the detected ventricular depolarization to the detected maximum peak amplitude in the second signal; (g) determining with said microcontroller a time t2 from the detected ventricular repolarization to the detected maximum peak amplitude in the second signal; (h) determining with said microcontroller a peak pulse arrival time (PPAT) based on times t1 and t2; and (i) determining with said microcontroller a value indicative of systolic pressure (SP) based on the PPAT. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An implantable system configured to monitor a patient'"'"'s arterial blood pressure, comprising:
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a first detector configured to detect ventricular depolarizations and ventricular repolarizations in cardiac cycles represented in a first signal that is indicative of electrical activity of a patient'"'"'s heart, wherein the first signal comprises an intracardiac electrogram (IEGM) or an electrocardiogram (ECG); a sensing circuit to obtain the first signal using implantable electrodes; a second detector configured to detect maximum peak amplitudes in cardiac cycles represented in a second signal indicative of mechanical activity of the patients'"'"' heart; an arterial blood pressure monitor configured to determine a time t1 from a detected ventricular depolarization to a detected maximum peak amplitude in the second signal; determine a time t2 from the detected ventricular repolarization to the detected maximum peak amplitude in the second signal; determine a peak pulse arrival time (PPAT) based on times t1 and t2; and
determine a value indicative of systolic pressure (SP) based on the PPAT. - View Dependent Claims (22, 23, 24, 25, 26)
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Specification