×

Three dimensional construct for the design and fabrication of physiological fluidic networks

  • US 8,147,562 B2
  • Filed: 09/23/2003
  • Issued: 04/03/2012
  • Est. Priority Date: 09/23/2002
  • Status: Active Grant
First Claim
Patent Images

1. A method of modeling and designing a physiologically based fluidic network in a three-dimensional construct for use as an organ simulant for a specific organ, comprising the steps of:

  • generating an initial design of an initial network in node-vessel format by stacking two-dimensional layers comprised of vessels connected by nodes and interconnecting the layers with vertical vessels such that the initial design is a three-dimensional design of a biological construct;

    translating the initial design from node-vessel format into a set of matrix equations relating a pressure and a resistance for each vessel, thereby defining flow behavior in the network;

    setting constraints on the set of matrix equations and determining a flow rate in each vessel, wherein the constraints include at least one physiological parameter associated with the specific organ;

    solving the set of matrix equations for the pressure and resistance of each vessel based on the flow rate in each vessel and the constraints;

    determining a geometry of each vessel on the basis of the corresponding resistance, thereby defining a final design of a final biological construct; and

    producing the final biological construct for use as an organ simulant.

View all claims
  • 4 Assignments
Timeline View
Assignment View
    ×
    ×