Shigella protein antigens and methods
First Claim
1. A vaccine composition for immunizing a mammal against Shigella comprising an amount of Shigella IcsP2 protein or SigA2 protein effective to elicit an immune response against Shigella, and a pharmaceutically acceptable carrier or diluent.
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Abstract
The present invention relates to protein antigens IcsP2 and SigA2 from Shigella that are common among numerous Shigella types and species and which can protect against shigellosis or other enteric infections when administered as vaccines. In addition, the present invention relates to antigens that are in common between Shigella species and enteroinvasive Escherichia coli (EIEC). The invention also relates to the use of antibodies raised against these antigens and of DNA probes for use in the diagnosis of Shigella and EIEC infections.
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Citations
18 Claims
- 1. A vaccine composition for immunizing a mammal against Shigella comprising an amount of Shigella IcsP2 protein or SigA2 protein effective to elicit an immune response against Shigella, and a pharmaceutically acceptable carrier or diluent.
- 2. A vaccine composition for immunizing a mammal against Shigella comprising an amount of Shigella IcsP2 protein effective to elicit an immune response against Shigella, and a pharmaceutically acceptable carrier or diluent.
- 4. A vaccine composition for immunizing a mammal against Shigella comprising an amount of Shigella SigA2 protein effective to elicit an immune response against Shigella, and a pharmaceutically acceptable carrier or diluent.
Specification